Optical properties of circulating human blood in the wavelength range 400-2500 NM
Optical properties of circulating human blood in the wavelength range 400-2500 NM
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DOI：
10.1117/1.429919
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发表时间：
1999-01-01
影响因子：
3.5
通讯作者：
Müller, G
中科院分区：
文献类型：
--
作者：
Roggan, A;Friebel, M;Müller, G
关于人体血液的光学性质μ（a）、μ（s）和g的知识对于激光医学和医学诊断中的许多诊断和治疗应用起着重要作用。他们强烈地依赖于生理参数，如氧饱和度，渗透压，流动条件，红细胞压积等积分球技术和逆蒙特卡罗模拟被施加到测量μ（a），μ（s），和g的循环人体血液。在633 nm处，红细胞压积为10%、氧饱和度为98%的人体血液的光学特性为：mu（a）为0.210 +/- 0.002 mm（-1），mu（s）为77.3 +/- 0.5 mm（-1），g因子为0.994 +/- 0.001。红细胞压积增加至50%导致吸收线性增加和散射减少。渗透压摩尔浓度和壁面剪切速率的变化导致所有三个参数的变化，而氧饱和度的变化只导致吸收系数的显着变化。在400-2500 nm波长范围内测量了氧合和脱氧血液的所有三个参数的光谱，表明血液吸收遵循血红蛋白和水的吸收行为。散射系数在波长大于500 nm时降低，约为λ（-17）;在整个波长范围内，g因子高于0.9。(C)1999年，美国光学仪器工程师学会。[S1083-3668（99）00501-8]。
Knowledge about the optical properties mu(a), mu(s), and g of human blood plays an important role for many diagnostic and therapeutic applications in laser medicine and medical diagnostics. They strongly depend on physiological parameters such as oxygen saturation, osmolarity, flow conditions, haematocrit, etc. The integrating sphere technique and inverse Monte Carlo simulations were applied to measure mu(a), mu(s), and g of circulating human blood. At 633 nm the optical properties of human blood with a haematocrit of 10% and an oxygen saturation of 98% were found to be 0.210 +/- 0.002 mm(-1) for mu(a), 77.3 +/- 0.5 mm(-1) for mu(s), and 0.994 +/- 0.001 for the g factor. An increase of the haematocrit up to 50% lead to a linear increase of absorption and reduced scattering. Variations in osmolarity and wall shear rate led to changes of all three parameters while variations in the oxygen saturation only led to a significant change of the absorption coefficient. A spectrum of all three parameters was measured in the wavelength range 400-2500 nm for oxygenated and deoxygenated blood, showing that blood absorption followed the absorption behavior of haemoglobin and water. The scattering coefficient decreased for wavelengths above 500 nm with approximately lambda(-17); the g factor was higher than 0.9 over the whole wavelength range. (C) 1999 Society of Photo-Optical Instrumentation Engineers. [S1083-3668(99)00501-8].