Effects of exercise training on coronary transport capacity.
Effects of exercise training on coronary transport capacity.
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运动训练对冠状动脉转运能力的影响。
DOI：
10.1152/jappl.1985.58.2.468
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Laughlin,MH
中科院分区：
文献类型：
--
作者：
Laughlin,MH
在8只安静对照和8只运动训练的麻醉犬中，通过确定基线和最高冠状动脉血流量之间的差异以及在冠状动脉灌注压恒定的情况下最大腺苷血管舒张期间获得的渗透性-表面积乘积（PS）来估计冠状动脉转运能力。对左冠状动脉的前降支分支进行插管，并在恒压条件下（约等于100 Torr）进行泵灌注，同时监测主动脉、中心静脉和冠状动脉灌注压、心率、心电图和冠状动脉流量。用单次注射指示剂扩散法测定心肌抽提物和~（51）Cr-乙二胺四乙酸的PS。腓肠肌、臀内侧肌和肱三头肌长头肌的琥珀酸脱氢酶活性显著增加，显示了16 +/- 1周运动训练计划的有效性。对照组和训练犬之间的静息冠状动脉血流量或PS无差异。在腺苷最大血管舒张期间，经过训练的狗在恒定流量下具有显著较低的灌注压，并且在恒定压力血管舒张下具有更大的冠状动脉血流量和PS。得出的结论是，狗的运动训练诱导增加冠状动脉运输能力，包括增加冠状动脉血流量（26%的控制）和毛细血管扩散能力（82%的控制）。
Coronary transport capacity was estimated in eight sedentary control and eight exercise-trained anesthetized dogs by determining the differences between base line and the highest coronary blood flow and permeability-surface area product (PS) obtained during maximal adenosine vasodilation with coronary perfusion pressure constant. The anterior descending branch of the left coronary artery was cannulated and pump-perfused under constant-pressure conditions (approximately equal to 100 Torr) while aortic, central venous, and coronary perfusion pressures, heart rate, electrocardiogram, and coronary flow were monitored. Myocardial extraction and PS of 51Cr-labeled ethylenediaminetetraacetic acid were determined with the single-injection indicator-diffusion method. The efficacy of the 16 +/- 1 wk exercise training program was shown by significant increases in the succinate dehydrogenase activities of the gastrocnemius, gluteus medialis, and long head of triceps brachii muscles. There were no differences between control and trained dogs for either resting coronary blood flow or PS. During maximal vasodilation with adenosine, the trained dogs had significantly lower perfusion pressures with constant flow and, with constant-pressure vasodilation, greater coronary blood flow and PS. It is concluded that exercise training in dogs induces an increased coronary transport capacity that includes increases in coronary blood flow capacity (26% of control) and capillary diffusion capacity (82% of control).