Computational analysis of the effect of valvular regurgitation on ventricular mechanics using a 3D electromechanics model.
Computational analysis of the effect of valvular regurgitation on ventricular mechanics using a 3D electromechanics model.
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DOI：
10.1007/s12576-014-0353-4
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发表时间：
2015-03
期刊：
影响因子：
--
通讯作者：
Trayanova N
中科院分区：
文献类型：
--
作者：
Lim KM;Hong SB;Lee BK;Shim EB;Trayanova N
使用三维机电模型的犬心室不同步性心力衰竭，我们研究了瓣膜返流的严重程度和心室机械反应之间的关系。结果表明，二尖瓣返流（MR）时室间隔和左室游离壁收缩末期张力明显低于主动脉瓣返流（AR）时。AR的每搏功高于MR。另一方面，两种情况下的每搏量差异不显著，表明AR可能会导致比MR更差的泵送效率，在消耗的能量和执行的工作。
Using a three-dimensional electromechanical model of the canine ventricles with dyssynchronous heart failure, we investigated the relationship between severity of valve regurgitation and ventricular mechanical responses. The results demonstrated that end-systolic tension in the septum and left ventricular free wall was significantly lower under the condition of mitral regurgitation (MR) than under aortic regurgitation (AR). Stroke work in AR was higher than that in MR. On the other hand, the difference in stroke volume between the two conditions was not significant, indicating that AR may cause worse pumping efficiency than MR in terms of consumed energy and performed work.