Are housing circumstances associated with faster epigenetic ageing?
Are housing circumstances associated with faster epigenetic ageing?
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DOI：
10.1136/jech-2023-220523
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发表时间：
2023-12-08
影响因子：
6.3
通讯作者：
Kumari, Meena
中科院分区：
文献类型：
--
作者：
Clair, Amy;Baker, Emma;Kumari, Meena
住房的许多方面都与健康有关。然而，住房和健康之间的途径，特别是住房的心理社会因素，还不太清楚。表观遗传学信息以及社会调查数据为探索生物衰老提供了机会，通过DNA甲基化测量，作为住房影响健康的潜在途径。我们使用了来自英国家庭纵向研究的住房和DNA甲基化数据，与英国家庭小组调查之前的调查回应相联系，覆盖了英国的成年人。我们探索表观遗传老化和住房环境之间的联系，无论是当代的还是历史的，使用等级回归。我们发现，住在私人出租的房子里与更快的生物衰老有关。重要的是，私人租房的影响(系数(SE)0.046年(0.011)vs直接拥有，p<；0.001)比经历过失业(系数0.027年(0.012)vs在职(p<；0.05))或曾经吸烟(系数0.021年(0.005)vs从不吸烟，p<；0.001)的影响更大。当我们将历史上的住房情况纳入分析时，我们发现反复拖欠住房和暴露在污染/环境问题中也与更快的生物老化有关。我们的结果表明，具有挑战性的住房环境通过更快的生物衰老对健康产生负面影响。然而，生物老龄化是可逆的，突显了住房政策变化改善健康的巨大潜力。
Numerous aspects of housing are associated with health. However, the pathways between housing and health, particularly the psychosocial elements of housing, are less well understood. Epigenetic information alongside social survey data offers an opportunity to explore biological ageing, measured using DNA methylation, as a potential pathway through which housing affects health. We use data on housing and DNA methylation from the UK Household Longitudinal Study, linked with prior survey responses from the British Household Panel Survey, covering adults in Great Britain. We explore the association between epigenetic ageing and housing circumstances, both contemporary and historical, using hierarchical regression. We find that living in a privately rented home is related to faster biological ageing. Importantly, the impact of private renting (coefficient (SE) 0.046 years (0.011) vs owned outright, p<0.001) is greater than the impact of experiencing unemployment (coefficient 0.027 years (0.012) vs employed, p<0.05) or being a former smoker (coefficient 0.021 years (0.005) vs never smoker, p<0.001). When we include historical housing circumstances in the analysis, we find that repeated housing arrears and exposure to pollution/environmental problems are also associated with faster biological ageing. Our results suggest that challenging housing circumstances negatively affect health through faster biological ageing. However, biological ageing is reversible, highlighting the significant potential for housing policy changes to improve health.
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表观遗传性衰老特征在癌症中连贯地改变了。
影响因子：
4.5
作者：
Lin Q;Wagner W
通讯作者：
Wagner W
全基因组甲基化谱揭示了人类衰老速度的定量观点。
影响因子：
16
作者：
Hannum, Gregory;Guinney, Justin;Zhao, Ling;Zhang, Li;Hughes, Guy;Sadda, SriniVas;Klotzle, Brandy;Bibikova, Marina;Fan, Jian-Bing;Gao, Yuan;Deconde, Rob;Chen, Menzies;Rajapakse, Indika;Friend, Stephen;Ideker, Trey;Zhang, Kang
通讯作者：
Zhang, Kang
DOI：
10.18632/aging.100908
发表时间：
2016-02
期刊：
Aging
影响因子：
--
作者：
Lin Q;Weidner CI;Costa IG;Marioni RE;Ferreira MR;Deary IJ;Wagner W
通讯作者：
Wagner W
影响因子：
7.7
作者：
Belsky DW;Caspi A;Corcoran DL;Sugden K;Poulton R;Arseneault L;Baccarelli A;Chamarti K;Gao X;Hannon E;Harrington HL;Houts R;Kothari M;Kwon D;Mill J;Schwartz J;Vokonas P;Wang C;Williams BS;Moffitt TE
通讯作者：
Moffitt TE
DOI：
10.18632/aging.101414
发表时间：
2018-04-18
期刊：
Aging
影响因子：
--
作者：
Levine ME;Lu AT;Quach A;Chen BH;Assimes TL;Bandinelli S;Hou L;Baccarelli AA;Stewart JD;Li Y;Whitsel EA;Wilson JG;Reiner AP;Aviv A;Lohman K;Liu Y;Ferrucci L;Horvath S
通讯作者：
Horvath S