Improved chiral separations using a polymerized dipeptide anionic chiral surfactant in electrokinetic chromatography: separations of basic, acidic, and neutral racemates.
Improved chiral separations using a polymerized dipeptide anionic chiral surfactant in electrokinetic chromatography: separations of basic, acidic, and neutral racemates.
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在电动色谱中使用聚合二肽阴离子手性表面活性剂改进手性分离：碱性、酸性和中性外消旋体的分离。
DOI：
10.1021/ac970037a
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发表时间：
1997
影响因子：
7.4
通讯作者：
Warner,IM
中科院分区：
文献类型：
--
作者：
Shamsi,SA;Macossay,J;Warner,IM
比较了两种高分子手性阴离子表面活性剂[聚（n -十一乙烯基-l-缬氨酸钠）（聚-l- suv）和聚（n -十一乙烯基-l-缬氨酸钠）（聚-l- suv）]作为假固定相用于碱性、酸性和中性对映体的手性分离。研究了pH、背景电解质的浓度和类型、聚合手性表面活性剂的浓度和注射尺寸等参数，以研究几种外消旋分析物的迁移行为并优化其手性分辨率。在相同单体浓度下，聚l- suv对阳离子对映体的迁移因子大于聚l- suv。相反，阴离子对映体的情况正好相反。然而，在这两种情况下，与poly-l-SUV相比，poly-l-SUV的手性识别明显增强。有趣的是，中性外消旋体的分离选择性和分辨率稍好于后者，但代价是较长的分析时间和较低的效率。
Two polymeric chiral anionic surfactants [poly(sodiumN-undecylenyl-l-valine) (poly-l-SUV) and poly(sodiumN-undecylenyl-l-valine-valine) (poly-l-SUVV)] are compared as pseudostationary phases for chiral separations of basic, acidic, and neutral enantiomers. Parameters such as pH, concentration and type of background electrolyte, concentration of polymerized chiral surfactants, and injection size were studied to investigate the migration behavior and optimize the chiral resolution of several racemic analytes. At equivalent monomer concentrations, the migration factors for cationic enantiomers were larger with poly-l-SUV than with poly-l-SUVV. In contrast, the reverse was true for anionic enantiomers. However, in both cases, chiral recognition was significantly enhanced with poly-l-SUVV as compared to that with poly-l-SUV. It is interesting to note that the separation selectivity and resolution of a neutral racemate were slightly better with the latter, but only at the expense of longer analysis time and lower efficiencies.