Increased risk of Parkinson's disease after depression - A retrospective cohort study
Increased risk of Parkinson's disease after depression - A retrospective cohort study
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DOI：
10.1212/wnl.58.10.1501
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发表时间：
2002-05-28
期刊：
影响因子：
9.9
通讯作者：
Buntinx, F
中科院分区：
文献类型：
--
作者：
Schuurman, AG;van den Akker, M;Buntinx, F
背景：抑郁症与许多躯体疾病的发生有关。没有PD的数据。目的：确定抑郁症是否与随后的帕金森病风险相关。方法：采用基于全科医学的回顾性队列研究设计。所有在1975-1990年间被诊断为抑郁症的受试者都被纳入其中，并与出生年份相同的从未被诊断为抑郁症的受试者配对。跟进工作已于2000年4月30日结束。根据年龄、性别和社会经济状况调整的Cox比例风险模型计算出危险比(HR)和95%可信区间。根据抑郁症诊断时的性别和年龄分组分别进行评估。结果：在1358例抑郁症患者中，19例发生了帕金森病，在67,570例非抑郁患者中，有259例发生了帕金森病。经多因素分析，抑郁组与非抑郁组的HR(95%CI)为3.13(1.95~5.01)。亚组中的关联与整体关联具有可比性。结论：抑郁症与随后的帕金森病的发病率之间存在很强的正相关关系。
Background: Depression has been linked to the occurrence of a number of somatic diseases. There are no data for PD. Objective: To determine if depression is associated with a subsequent risk for PD. Methods: A retrospective cohort study design based in general practice was applied. All subjects diagnosed with depression between 1975 and 1990 were included and matched with subjects with the same birth year who were never diagnosed with depression. Follow-up ended at April 30, 2000. Hazard ratios (HR) and 95% CI were calculated using Cox proportional hazards models adjusted for age, sex, and socioeconomic status. Subgroups based on sex and age at diagnosis of depression were evaluated separately. Results: Among the 1,358 depressed subjects, 19 developed PD, and among the 67,570 nondepressed subjects, 259 developed PD. The HR (95% CI) for depressed vs nondepressed subjects was 3.13 (1.95 to 5.01) in multivariable analysis. Associations in subgroups were comparable with the overall association. Conclusion: A strong positive association was found between depression and subsequent incidence of PD.