DOES LOWER SUBJECTIVE SOCIAL STATUS YIELD RISKIER BIOMARKER PROFILES?
DOES LOWER SUBJECTIVE SOCIAL STATUS YIELD RISKIER BIOMARKER PROFILES?
复制标题
主观社会地位较低是否会导致生物标志物概况风险较高？
DOI：
10.1017/s002193201400042x
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发表时间：
2015
影响因子：
1.5
通讯作者：
Boyce,WThomas
中科院分区：
文献类型：
--
作者：
Gersten,Omer;Timiras,PaolaS;Boyce,WThomas
社会地位低的客观和最近的主观衡量标准都与健康状况不佳有关。然而，目前尚不清楚这种地位通过何种精确的生理机制可能影响健康，尽管有人提出，地位较低的人可能具有更失调的生物标志物特征（因此对较差的健康构成更大的风险）。本研究的主要目的是调查较低的主观社会地位是否与风险较高的神经内分泌生物标志物谱相关。数据来自社会环境和衰老生物标志物研究（SEBAS），这是2000年在台湾进行的一项具有全国代表性的台湾男性和女性（年龄54-91岁）调查。五个神经内分泌标志物（皮质醇，硫酸脱氢表雄酮（DHEAS），肾上腺素，去甲肾上腺素和多巴胺）进行了分析，分别和集体在一个指数称为神经内分泌非稳态负荷（NAL）的状态-自我报告和通过客观社会经济地位（SES）指标测量。对于生物标志物DHEAS，在其水平和状态测量之间发现了一些联系，但对于其他标志物和NAL指数几乎没有发现任何联系。本文的总体负面发现将进一步得到支持，更多和不同的神经内分泌系统功能的测量和调查中主观社会地位问题的重新排序，在台湾的地位问题（有SES提示）之前，有人问过（没有提示）。
Both objective and, more recently, subjective measures of low social status have been linked to poor health outcomes. It is unclear, however, through which precise physiological mechanisms such standing may influence health, although it has been proposed that those of lower status may have biomarker profiles that are more dysregulated (and hence pose a greater risk for poorer health). The main objective of this study was to investigate whether lower subjective social standing is associated with riskier neuroendocrine biomarker profiles. Data were from the Social Environment and Biomarkers of Aging Study (SEBAS), a nationally representative survey of Taiwanese men and women (ages 54–91) conducted in Taiwan in 2000. Five neuroendocrine markers (cortisol, dehydroepiandrosterone sulphate (DHEAS), adrenaline, noradrenaline and dopamine) were analysed both separately and collectively in an index termed neuroendocrine allostatic load (NAL) in relation to status – both self-reported and as measured through objective socioeconomic status (SES) indicators. For the biomarker DHEAS, some connection was found between its levels and the measures of status, but for the other markers and the NAL index almost no connection was found. The overall negative finding of this paper would be further supported with more and different measures of neuroendocrine system function and a reordering of the subjective social status questions in the survey such that the one probing about status in the community (that has no prompt) was asked before the one probing about status in all of Taiwan (which has a SES prompt).