Formin' cellular structures: Physiological roles of Diaphanous (Dia) in actin dynamics.
Formin' cellular structures: Physiological roles of Diaphanous (Dia) in actin dynamics.
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DOI：
10.4161/cib.27634
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发表时间：
2013-11-01
影响因子：
--
通讯作者：
Grosshans J
中科院分区：
文献类型：
--
作者：
Bogdan S;Schultz J;Grosshans J
透明蛋白（Dia）家族的成员是基本肌动蛋白驱动的细胞过程的关键调节因子，从酵母到人类都是保守的。研究人员已经发现了细胞形态，细胞运动，细胞极性和细胞分裂中的各种生理作用，这些作用涉及将细胞塑造成组织和器官。许多结合伙伴的鉴定导致了我们对Dia蛋白差异功能的理解取得了实质性进展。遗传学方法和新的显微镜技术允许重要的新的见解，他们的本地化，活动和分子调控原则。
Members of the Diaphanous (Dia) protein family are key regulators of fundamental actin driven cellular processes, which are conserved from yeast to humans. Researchers have uncovered diverse physiological roles in cell morphology, cell motility, cell polarity, and cell division, which are involved in shaping cells into tissues and organs. The identification of numerous binding partners led to substantial progress in our understanding of the differential functions of Dia proteins. Genetic approaches and new microscopy techniques allow important new insights into their localization, activity, and molecular principles of regulation.