Delusions and the Role of Beliefs in Perceptual Inference
Delusions and the Role of Beliefs in Perceptual Inference
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DOI：
10.1523/jneurosci.1778-13.2013
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发表时间：
2013-08-21
影响因子：
5.3
通讯作者：
Sterzer, Philipp
中科院分区：
文献类型：
--
作者：
Schmack, Katharina;de Castro, Ana Gomez-Carrillo;Sterzer, Philipp
妄想是毫无根据但顽固的信念，是精神障碍的症状。在健康人群中也发现了不同程度的妄想意念。在这里，我们经验验证了神经认知模型，解释了形成和持久性的错觉信念的知觉推断改变。在一项对健康参与者进行的行为和功能神经影像学联合研究中，我们使用模糊的视觉刺激来探讨妄想倾向与学习预测对感知的影响之间的关系。抽象思维与较少的知觉稳定性，但更强的信念诱导的偏见的看法，增强功能之间的连接额叶区编码的信念和感觉区编码的看法。这些发现表明，导致知觉不稳定的较低水平预测减弱与妄想信念的出现有关。相比之下，更强的高层次预测，塑造知觉符合信念可能有助于顽固的持续性妄想的信念。
Delusions are unfounded yet tenacious beliefs and a symptom of psychotic disorder. Varying degrees of delusional ideation are also found in the healthy population. Here, we empirically validated a neurocognitive model that explains both the formation and the persistence of delusional beliefs in terms of altered perceptual inference. In a combined behavioral and functional neuroimaging study in healthy participants, we used ambiguous visual stimulation to probe the relationship between delusion-proneness and the effect of learned predictions on perception. Delusional ideation was associated with less perceptual stability, but a stronger belief-induced bias on perception, paralleled by enhanced functional connectivity between frontal areas that encoded beliefs and sensory areas that encoded perception. These findings suggest that weakened lower-level predictions that result in perceptual instability are implicated in the emergence of delusional beliefs. In contrast, stronger higher-level predictions that sculpt perception into conformity with beliefs might contribute to the tenacious persistence of delusional beliefs.