Role of acute phase proteins in the immune response of rabbits infected with Trypanosoma evansi
Role of acute phase proteins in the immune response of rabbits infected with Trypanosoma evansi
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DOI：
10.1016/j.rvsc.2013.01.029
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发表时间：
2013-08-01
影响因子：
2.4
通讯作者：
Monteiro, Silvia Gonzalez
中科院分区：
文献类型：
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作者：
Costa, Marcio Machado;dos Anjos Lopes, Sonia Terezinha;Monteiro, Silvia Gonzalez
本研究的目的是描述急性时相蛋白（APP）在实验感染伊氏锥虫（T。evansi），并与血清免疫球蛋白水平进行相关性分析，以验证APP与家兔免疫应答的关系。本实验共使用12只动物，分为对照组和感染组，每组6只兔。实验期为118天，并在感染后（PI）第0、5、20、35、65、95和118天收集血液。T.一旦感染的动物显示C-反应蛋白、触珠蛋白、α 2-巨球蛋白和IgM水平增加，伊氏病毒刺激APP和免疫球蛋白的产生。本研究中观察到的IgM水平的升高，当与C-反应蛋白和触珠蛋白水平的升高相关时，表明这些蛋白质参与宿主对鞭毛原虫的防御，可能参与控制感染T. evansi (c)2013爱思唯尔有限公司保留所有权利。
The aim of this study was to characterize the response of acute phase proteins (APP) in rabbits experimentally infected with Trypanosoma evansi (T. evansi), and to relate the findings with serum immunoglobulins levels, in order to verify the relation between APP and the immune response of rabbits. A total of 12 animals were used in this experiment and divided into 2 groups, control and infected, of six rabbits each. The experimental period was 118 days, and blood was collected on days 0, 5, 20, 35, 65, 95 and 118 post-infection (PI). The infection with T. evansi stimulated APP and immunoglobulins production, once the infected animals showed an increase in C-reactive protein, haptoglobin, alpha 2-macroglobulin and IgM levels. The elevation in IgM levels observed in this study, when related to the increase in C-reactive protein and haptoglobin levels, suggests the involvement of these proteins in host defense against flagellated protozoa, with possible participation in the control of the parasitemia in rabbits infected with T. evansi. (c) 2013 Elsevier Ltd. All rights reserved.