PRETRANSFUSION BLOOD IRRADIATION - CLINICAL RATIONALE AND DOSIMETRIC CONSIDERATIONS
PRETRANSFUSION BLOOD IRRADIATION - CLINICAL RATIONALE AND DOSIMETRIC CONSIDERATIONS
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DOI：
10.1118/1.596809
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发表时间：
1992-05-01
期刊：
影响因子：
3.8
通讯作者：
FEBO, R
中科院分区：
文献类型：
--
作者：
MASTERSON, ME;FEBO, R
在输注给免疫抑制患者之前对血液进行辐照是一种越来越常见的用于预防移植物抗宿主病的技术。描述了血液辐照器校准的技术程序，包括确定绝对剂量率和血液体积上的相对剂量分布。市售辐照器的剂量率测量结果表明，与制造商提供的校准值存在 + 5% 至 - 13% 的差异，并且辐照体积上相对剂量率的变化范围为 70% 至 180%。讨论了这些发现的临床意义以及准确剂量测定的必要性。
The irradiation of blood before transfusion into immunosuppressed patients is an increasingly common technique used to prevent graft-versus-host disease. A technical procedure is described for the calibration of blood irradiators, including the determination of absolute dose rate and relative dose distribution over the blood volume. Results of dose rate measurements on commercially available irradiators indicate differences of + 5% to - 13% with manufacturer-supplied calibrations and variations in the relative dose rate over the irradiation volume from 70% to 180%. The clinical implications of these findings and the need for accurate dosimetry are discussed.