Differential development of behavioral tolerance and the subsequent hedonic effects of alcohol in AA and ANA rats
Differential development of behavioral tolerance and the subsequent hedonic effects of alcohol in AA and ANA rats
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DOI：
10.1007/s002130000477
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发表时间：
2000-09-01
影响因子：
3.4
通讯作者：
Briscoe, RJ
中科院分区：
文献类型：
--
作者：
Gauvin, DV;Baird, TJ;Briscoe, RJ
基本原理：对酒精行为影响的耐受性发展至少有两种方式可以与随后的摄入量相互作用：1）对酒精奖励或强化效应本身的耐受性可能导致消费增加，2）对酒精厌恶效应的耐受性可能会揭露：酒精的奖励效应。这两种机制可能与先前存在的酗酒遗传特征存在差异。目的：酒精的主观属性进行了评估，在选择性繁殖的AA和ANA大鼠的耐受性发展后，酒精的行为破坏性的影响，按下性能。研究方法：训练大鼠在FR30食物呈现时间表下按下杠杆。使用典型的给药前后设计，利用依赖于组的不同的醉酒练习机会来促进仅接受醉酒练习的组中酒精耐受性的发展。随后，训练大鼠将酒精与独特的位置和味觉刺激相关联，以评估各组中接近或避免酒精相关线索的相对变化。结果：AA和ANA大鼠组给予访问中毒的做法表现出耐受性的发展。这些群体随后条件化的地方偏好，并未能发展条件化的味觉厌恶酒精。被动酒精暴露在ANA大鼠的位置偏好和延迟味觉条件反射的发展。AA大鼠暴露于被动酒精暴露未能条件的地方偏好和快速味觉厌恶。生理盐水对照组大鼠未能发展耐受性或位置偏好，但条件是一个强大的酒精诱导的味觉厌恶。结论：AA和ANA大鼠对慢性酒精暴露的行为学和药代动力学反应不同。补偿反应与接近回避行为的相互作用似乎是在AA大鼠的醉酒练习和ANA大鼠系的醉酒练习和被动暴露过程中学习的。
Rationale: There at least two ways in which tolerance development to alcohol's behavioral effects could interact with its subsequent intake: 1) tolerance to alcohol's reward or reinforcing effects per se could lead to increased consumption, and 2) tolerance to alcohol's aversive effects could unmask: alcohol's rewarding effects. These two mechanisms may differentially interact with preexisting genetic traits underlying alcoholism. Objectives: Alcohol's subjective attributes were assessed in selectively bred AA and ANA rats after the development of tolerance to alcohol's behaviorally disruptive effects on lever-press performance. Methods: Rats were trained to press a lever under an FR30 schedule of food presentations, Group-dependent differential access to intoxicated practice, using a typical pre-post drug administration design, was utilized to promote the development of alcohol tolerance in only the group receiving intoxicated practice sessions. Subsequently, rats were trained to associate alcohol with unique place and taste stimuli in order to assess the relative changes in the approach towards, or avoidance of alcohol-related cues in each group. Results: Groups of AA and ANA rats given access to intoxicated practice demonstrated tolerance development. These groups subsequently conditioned place preferences and failed to develop conditioned taste aversions to alcohol. Passive alcohol exposure in the ANA rats set the occasion for the development of a place preference and delayed taste conditioning. AA rats exposed to passive alcohol exposure failed to condition place preferences and developed rapid taste aversions. Saline control rats failed to develop tolerance or place preferences but did condition a robust alcohol-induced taste aversion. Conclusions: AA and ANA rats differ in their behavioral and pharmacokinetic response to chronic alcohol exposure. Compensatory responses interacting with approach-avoidance behaviors appear to be learned during intoxicated practice in the AA rats and during both intoxicated practice and passive exposure in the ANA rat line.