Infiltration of dendritic cells and NK cells into the sentinel lymph node in oral cavity cancer
Infiltration of dendritic cells and NK cells into the sentinel lymph node in oral cavity cancer
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DOI：
10.1016/j.oraloncology.2004.07.004
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发表时间：
2005-01-01
期刊：
影响因子：
4.8
通讯作者：
Furuya, N
中科院分区：
文献类型：
--
作者：
Sakakura, K;Chikamatsu, K;Furuya, N
前哨淋巴结(SLN)被认为是第一个肿瘤引流的淋巴结，可能是肿瘤抗原激活的起始部位。为阐明SLN的免疫功能，对12例口腔癌患者共89个无肿瘤区淋巴结(41个SLN和48个非SLN)进行免疫组织化学染色，检测DC和NK细胞的浸润情况。S-100+和CD1a+DC在SLN中的表达明显高于非SLN。对pN0和pN+患者的分析显示，pN0患者和PN+患者中仅S-100+的DC标志物在SLN中显著丰富。此外，pN+患者CD83+DC的浸润明显少于pN0患者。这些结果表明，SLN患者比非SLN患者发生更显著的抗癌免疫反应。然而，疾病的进展，包括结节病，可能会引起全身性免疫抑制。(C)2004爱思唯尔有限公司。保留所有权利。
The sentinel lymph node (SLN) is regarded as the first tumor-draining lymph node, which may be the initial site activated by tumor antigens. To clarify the immunological functions of SLNs, a total of 89 tumor-free regional lymph nodes (41 SLNs and 48 non-SLNs) were obtained from 12 patients with oral cavity cancer, and infiltration of both DCs and NK cells was determined by immunohistochemistry. S-100+ and CD1a+ DCs infiltrated significantly into SLNs compared to non-SLNs. Analysis in each of the pN0 and pN+ patients showed that all the DC markers in pN0 patients and only S-100+ in pN+ patients were significantly more abundant in SLNs. Moreover, infiltration of CD83+ DCs was less in pN+ patients than in pN0 patients. These results suggest that more significant immune responses against cancer occur in SLNs than in non-SLNs. However the progression of disease including nodal disease may cause systemic immunosuppression. (C) 2004 Elsevier Ltd. All rights reserved.