Evaluating different aspects of prospective memory in amnestic and nonamnestic mild cognitive impairment.
Evaluating different aspects of prospective memory in amnestic and nonamnestic mild cognitive impairment.
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DOI：
10.1155/2014/805929
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Loewenstein DA
中科院分区：
文献类型：
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作者：
Hernandez Cardenache R;Burguera L;Acevedo A;Curiel R;Loewenstein DA
前瞻记忆是一种常见的症状，但在大多数轻度认知障碍(MCI)的临床和研究研究中并未正式评估。本研究采用迈阿密前瞻记忆测验(MPMT)对遗忘性轻度认知障碍(AMCI)、非遗忘性认知障碍(NAMCI)和认知正常(CN)老年人进行了测评。该范式的一个独特方面是，参与者根据执行意图、对任务特定要素的回忆准确性以及是否需要提醒线索来评分。MPMT事件相关(ER)、组合时间相关(TR)分量表和MPMT总分对于aMCI受试者具有良好的重测稳定性。在48.6%的aMCI、29.4%的NAMCI和10.0%的正常老年参与者中观察到MPMT损害。前瞻记忆缺陷在患有MCI的参与者中很常见，几乎三分之一的NAMCI参与者会发生这种缺陷。执行意图和对提示线索的需要明显比对任务具体细节的回顾记忆受损得多。结论是，对前瞻记忆的不同因素的评估在MCI研究中很重要，而无法记住预期动作是阿尔茨海默病风险人群的一个重要特征。
Prospective memory, the inability to remember an intended action, is a common complaint, but not formally assessed in most clinical and research studies of mild cognitive impairment (MCI). In this study, patients with amnestic mild cognitive impairment (aMCI), non-amnestic cognitive impairment (naMCI), and cognitively normal (CN) elders were assessed using the Miami Prospective Memory Test (MPMT). A unique aspect of the paradigm was that participants were scored for intention to perform, accuracy in recollection for specific elements of the task, and the need for reminder cues. Excellent test-retest stability was obtained for MPMT Event-Related (ER), combined Time-Related (TR) subscales, and total MPMT score for aMCI subjects. MPMT impairments were observed in 48.6% of aMCI, 29.4% of naMCI, and 10.0% of normal elderly participants. Prospective memory deficits were common in participants with aMCI, and occurred in almost a third of naMCI participants. Intention to perform and need for reminder cues were significantly more impaired than retrospective memory for specific details of the task. It is concluded that assessment of different elements of prospective memory is important in MCI research and that inability to remember intended actions is a significant feature in those as risk for Alzheimer's disease.