Progress in the Management of Primary Aldosteronism.
Progress in the Management of Primary Aldosteronism.
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DOI：
10.1093/ajh/hpy018
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发表时间：
2018-04-13
影响因子：
3.2
通讯作者：
Satoh F
中科院分区：
文献类型：
--
作者：
Morimoto R;Omata K;Ito S;Satoh F
原发性醛固酮增多症（PA）是继发性高血压的主要病因之一，占所有高血压患者的5-10%，占顽固性高血压患者的20%。重要的是，那些单侧疾病可以手术治愈时，适当的诊断。另一方面，到目前为止，只有非常有限的一部分疑似患有PA的人接受了筛查，诊断或治疗。随着目前医学技术和遗传学研究的进步，PA的知识不断积累，最近的成就也被记录在PA患者的护理中。本次审查的目的是集中描述以下更新的主题; PA筛查的重要性，无论是在一般和专业设置和仔细解释的筛选数据，最近取得的成就，激素测定和采样方法及其临床意义，并扩大知识PA遗传学。改善后处理过程和新的治疗方案，以及更好地了解PA的发病机制的基础上遗传研究，可能会导致增加治愈和更好地照顾病人。
Primary aldosteronism (PA) is now considered as one of leading causes of secondary hypertension, accounting for 5–10% of all hypertensive patients and more strikingly 20% of those with resistant hypertension. Importantly, those with the unilateral disease could be surgically cured when diagnosed appropriately. On the other hand, only a very limited portion of those suspected to have PA has been screened, diagnosed, or treated to date. With current advancement in medical technologies and genetic research, expanding knowledge of PA has been accumulated and recent achievements have also been documented in the care of those with PA. This review is aimed to have focused description on updated topics of the following; importance of PA screening both in the general and specialized settings and careful interpretation of screening data, recent achievements in hormone assays and sampling methods and their clinical relevance, and expanding knowledge on PA genetics. Improvement in workup processes and novel treatment options, as well as better understanding of the PA pathogenesis based on genetic research, might be expected to result in increased cure and better care of the patients.
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影响因子：
4.6
作者：
Åkerström T;Maharjan R;Sven Willenberg H;Cupisti K;Ip J;Moser A;Stålberg P;Robinson B;Alexander Iwen K;Dralle H;Walz MK;Lehnert H;Sidhu S;Gomez-Sanchez C;Hellman P;Björklund P
通讯作者：
Björklund P
影响因子：
30.8
作者：
Azizan, Elena A. B.;Poulsen, Hanne;Brown, Morris J.
通讯作者：
Brown, Morris J.
影响因子：
5.8
作者：
Funder, John W.;Carey, Robert M.;Young, William F., Jr.
通讯作者：
Young, William F., Jr.
DOI：
10.1126/science.1198785
发表时间：
2011-02-11
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Choi M;Scholl UI;Yue P;Björklund P;Zhao B;Nelson-Williams C;Ji W;Cho Y;Patel A;Men CJ;Lolis E;Wisgerhof MV;Geller DS;Mane S;Hellman P;Westin G;Åkerström G;Wang W;Carling T;Lifton RP
通讯作者：
Lifton RP
影响因子：
5.8
作者：
Betz, Matthias J.;Degenhart, Christoph;Reincke, Martin
通讯作者：
Reincke, Martin