Effective downregulation of HLA-A*2 and HLA-B*57 by primary human immunodeficiency virus type 1 isolates cultured from elite suppressors.
Effective downregulation of HLA-A*2 and HLA-B*57 by primary human immunodeficiency virus type 1 isolates cultured from elite suppressors.
复制标题
从精英抑制病毒中培养的原代人类免疫缺陷病毒 1 型分离株可有效下调 HLA-A*2 和 HLA-B*57。
DOI：
10.1128/jvi.00306-09
复制
发表时间：
2009
影响因子：
5.4
通讯作者：
Blankson,JoelN
中科院分区：
文献类型：
--
作者：
Nou,Eric;Zhou,Yan;Nou,DamarisD;Blankson,JoelN
Elite controllers or suppressors (ES) are human immunodeficiency virus type 1 (HIV-1)-infected patients who control viral replication to <50 copies/ml without antiretroviral therapy. Downregulation of HLA class I molecules is an important mechanism used by HIV-1 to evade the immune system. In this study, we showed that primary isolates from ES are as effective as isolates obtained from patients with progressive HIV-1 disease at downregulating HLA-A*2 and HLA-B*57 molecules on primary CD4+T cells. Thus, a diminished ability of viral isolates from ES to evade HIV-specific immune responses probably does not contribute to the control of viral replication in these patients.
