PROGNOSIS OF A POSITIVE TUBERCULIN REACTION IN CHILDHOOD AND ADOLESCENCE
PROGNOSIS OF A POSITIVE TUBERCULIN REACTION IN CHILDHOOD AND ADOLESCENCE
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DOI：
10.1093/oxfordjournals.aje.a121593
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发表时间：
1974-01-01
影响因子：
5
通讯作者：
WOOLPERT, SF
中科院分区：
文献类型：
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作者：
COMSTOCK, GW;LIVESAY, VT;WOOLPERT, SF
在1949-1951年对波多黎各儿童进行卡介苗和盖林疫苗接种的对照试验过程中，鉴定了82，269例对1或10个结核菌素单位的纯化蛋白衍生物的反应者。在最初测试后的18至20年间，在这些结核菌素反应者中确定了1400例结核病病例。主要危险因素是年龄。四岁以下儿童的结核病发病率最高，病情最严重。第二个发病高峰出现在20岁左右。在所有年龄段中，对结核菌素敏感性最强的儿童继发结核病的比率最高。女性和城市居民的风险略高于男性和农村居民。在白色和黑色反应者之间基本上没有发现结核病风险的差异。由于结核病感染者的风险似乎持续一生，预防性治疗的需要高度依赖于年龄，并在相当大但较小的程度上依赖于结核菌素的敏感程度。
In the course of a controlled trial of bacillus of Calmette and Guerin vaccination among Puerto Rican children in 1949–1951, 82, 269 reactors to 1 or 10 tuberculin units of purified protein derivative were identified. During the 18 to 20 years after initial testing, 1400 cases of tuberculosis were identified among these tuberculin reactors. The major risk factor was age. Children under four years of age had the highest tuberculosis rates and the most serious disease. A secondary peak of incidence was observed at about 20 years of age. At all ages, children with the strongest sensitivity to tuberculin had the highest rates of subsequent tuberculosis. The risk for females and for urban residents was slightly greater than for males and rural residents. Essentially no difference in tuberculosis risk was found between white and black reactors. Because the risk of tuberculosis among infected persons appears to persist for a lifetime, the need for preventive treatment is highly dependent on age, and to a considerable but lesser extent on degree of tuberculin sensitivity.