THE VIABILITY OF NEAR-NORMAL IRRADIATED CHROMOSOMES
THE VIABILITY OF NEAR-NORMAL IRRADIATED CHROMOSOMES
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DOI：
10.1080/09553005914550241
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发表时间：
1959-01-01
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影响因子：
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通讯作者：
BATEMAN, AJ
中科院分区：
文献类型：
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作者：
BATEMAN, AJ
在排除主要突变后，无论是致命的还是半致命的，雄性果蝇的x染色体在精子中辐照后的生存能力略有下降，但这是非常显著的。平均生存力的变化伴随着方差几乎不显著的增加。另一方面，卵子辐照虽然会产生预期的主要突变，但几乎不会产生任何次要突变。这些结果表明突变的幅度非常小，频率非常高。考虑了以下几种可能性。所有受辐照的染色体生存能力普遍下降，其数量与剂量成正比。在一个高度可变的位点上发生突变。突变沿着染色体的整个长度分布，每个突变使生存能力降低1%。在2000年以后，每条染色体的最大突变频率将大于两个。多基因突变的平均影响是使生存能力降低1%或更少。
After the exclusion of major mutations, both lethals and semi-lethals, the viability in the Drosophila male of X-chromosomes irradiated in sperm shows a slight reduction, which is, nevertheless, highly significant. The change in mean viability is accompanied by a barely significant increase in variance. On the other hand, irradiation of eggs, though yielding the expected major mutations, produces few if any minor mutations. These results indicate mutations of very low magnitude and very high frequency. The following alternative possibilities are considered. A general reduction in viability of all irradiated chromosomes, by an amount proportional to dose. Mutation at a single highly mutable locus. Mutations distributed along the entire length of the chromosome and each reducing viability by 1 per cent. The maximum frequency after 2000 r would be greater than two mutations per chromosome. Polygenic mutations with an average effect reducing viability by 1 per cent or less.