Concise asymmetric total synthesis of (−)-patchouli alcohol
Concise asymmetric total synthesis of (−)-patchouli alcohol
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DOI：
10.1039/c7qo00459a
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发表时间：
2017-09
影响因子：
5.4
通讯作者：
Guangyang Xu;G. Lin;Bingfeng Sun
中科院分区：
文献类型：
--
作者：
Guangyang Xu;G. Lin;Bingfeng Sun
以简洁的方式完成了(−)-广藿香醇的不对称全合成。关键反应包括高度非对映和对映选择性形式有机催化[4 + 2]环加成反应、自由基脱硝反应和氧化羧化反应。去甲广藿烯醇的正式合成也已实现。
The asymmetric total synthesis of (−)-patchouli alcohol was accomplished in a concise manner. Key reactions include a highly diastereo- and enantioselective formal organocatalytic [4 + 2] cycloaddition reaction, a radical denitration reaction, and an oxidative carboxylation reaction. The formal synthesis of norpatchoulenol was achieved as well.