Magnesium depletion as a cause of refractory potassium repletion.
Magnesium depletion as a cause of refractory potassium repletion.
复制标题
镁缺乏是难治性钾补充的一个原因。
作者：
R. Whang;E. Flink;T. Dyckner;P. Wester;J. Aikawa;M. Ryan
由于钾在医学实践中的重要性，重要的是要考虑影响细胞内和细胞外钾完整性的因素。今天的临床医生在处理低钾血症和高钾血症方面都很熟练。然而，医生可能对镁在钾稳态中的作用知之甚少。到目前为止的实验观察支持了镁和钾代谢密切相关的观点。在大鼠中，饮食中的镁缺乏伴随着肌钾的耗竭，这是在提供钾的情况下发生的。2钾和镁的同时耗竭导致肌肉钾的损失比单独钾耗竭时更大。3在钾和镁缺乏的大鼠中，肌细胞的钾再利用不是最优的，除非同时纠正钾和镁的缺乏。4因此，镁似乎不仅在维持细胞K方面，而且在细胞K的保存和再利用方面也是重要的。5本实验
Because of the significance of potassium in the practice of medicine, it is important to consider factors that influence the integrity of intracellular and extracellular K. Clinicians today are skilled in managing hypokalemia as well as hyperkalemia. However, physicians may be less aware of the role of magnesium in K homeostasis. Experimental observations to date support the view that Mg and K metabolism are closely linked. Dietary Mg depletion in the rat is accompanied by muscle K depletion, which occurs despite provision of K.1,2Concurrent K and Mg depletion results in a greater loss of muscle K than with K depletion alone.3In K- and Mg-deficient rats, muscle-cell K repletion is not optimized unless both K and Mg deficits are simultaneously corrected.4Thus, Mg appears to be important not only in maintenance of cell K but also in conservation and repletion of cell K.5These experimental