Results of early curettage of giant congenital melanocytic nevi; a report of eight cases and review of the literature
Results of early curettage of giant congenital melanocytic nevi; a report of eight cases and review of the literature
复制标题
先天性巨大黑素细胞痣早期刮除术的结果
DOI：
10.1007/s00238-008-0260-0
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发表时间：
2008
影响因子：
0.5
通讯作者：
C. Horst
中科院分区：
文献类型：
--
作者：
Laura H. Zaal;W. Mooi;H. S. Smitt;C. Horst
这项研究的目的是调查巨大先天性黑色素细胞痣(GCMN)早期刮除后的长期美容和肿瘤学结果。在门诊部对患有GCMN的新生儿在4周内进行刮宫治疗，并进行至少2年的随访。采用患者和观察者瘢痕评定量表(POAS)评价瘢痕形成情况。对活检标本进行分析。在9年的时间里，8名新生儿接受了治疗。平均随访期为5.6年。6例(75%)患者刮除皮肤后出现再色素沉着，5例多毛。1例患者形成增生性瘢痕，其余患者形成良好的瘢痕。所有患者均未患上黑色素瘤。活检标本显示刮除后皮肤中有痣细胞。在50%的患者中，刮除后会出现严重的再色素沉着。由于这种治疗并不能去除所有的痣细胞，所以长期的随访对于发现恶变是必不可少的。
The aim of this study was to investigate the long-term cosmetic and oncologic results following early curettage of giant congenital melanocytic nevi (GCMN). Neonates with GCMN treated with curettage within 4 weeks of age and with a minimum follow-up of 2 years were evaluated at the outpatient department. Scar formation was evaluated by means of the patient and observer scar assessment scale (POSAS). Biopsy specimens were analysed. In 9 years, eight neonates were treated. The mean follow-up period was 5.6 years. Six (75%) patients developed re-pigmentation of the curetted skin, hypertrichosis returned in five cases. One patient developed hypertrophic scars, all others formed good scars. None of the patients developed a melanoma. Biopsy specimens showed nevus cells in the skin after curettage. In 50% of the patients curettage is followed by severe re-pigmentation. Since this treatment does not remove all nevus cells, long-term follow-up is essential to detect malignant transformation.