Clinical assessment and prevalence of parkinsonism in Japanese elderly people
Clinical assessment and prevalence of parkinsonism in Japanese elderly people
复制标题
日本老年人帕金森病的临床评估和患病率
DOI：
10.1111/ane.12472
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发表时间：
2016
影响因子：
3.5
通讯作者：
Nakashima K
中科院分区：
文献类型：
--
作者：
Nakashita S;Wada-Isoe K;Uemura Y;Tanaka K;Yamamoto M;Yamawaki M;Nakashima K
帕金森氏症常见于老年人。为了明确帕金森相关疾病和病症的患病率，我们在日本西部的一个乡村岛屿城镇Ama - cho进行了一项基于人口的研究。方法924名65岁及以上居住在本镇的老年人。在2008年至2011年期间，参与者通过标准化的神经检查量表进行评估，并在2010年进行了脑部核磁共振成像。根据使用改进的统一帕金森病评定量表和标准化神经系统检查的评估结果，参与者被诊断为患有帕金森病或轻度帕金森症状（MPS），或显示正常的运动状况（M - normal）。结果在筛查的729名参与者中，70名受试者被诊断为帕金森病，对应的粗患病率为9.6% (95% CI, 7.9-11.3%)，而167名MPS受试者（22.9%）和492名M - normal受试者（67.5%）被观察到。帕金森病被发现与多种疾病有关，如血管性帕金森病、路易体病、阿尔茨海默病（AD）和特发性常压脑积水。在痴呆患者中，非阿尔茨海默氏症痴呆组帕金森比例较高。结论(5)老年帕金森病与多种疾病有关。人们还发现，帕金森病通常与认知障碍有关。
BackgroundParkinsonism is often observed in the elderly. To clarify the prevalence of parkinsonism‐associated diseases and conditions, we conducted a population‐based study in a rural island town in western Japan, Ama‐cho.MethodsParticipants included 924 subjects aged 65 years or older residing in the town. Between 2008 and 2011, participants were assessed via standardized neurological examination scales, and Brain MRIs were carried out in 2010. Based on the results of assessment using the modified Unified Parkinson's Disease Rating Scale and a standardized neurological examination, participants were diagnosed as having parkinsonism or mild parkinsonian signs (MPS), or as displaying normal motor conditions (M‐normal).ResultsOf the 729 participants screened, 70 subjects were diagnosed as having parkinsonism, corresponding to a crude prevalence rate of 9.6% (95% CI, 7.9–11.3%), while 167 MPS subjects (22.9%) and 492 subjects experiencing M‐normal (67.5%) were observed. Parkinsonism was found in association with various diseases such as Vascular parkinsonism, Lewy body disease, Alzheimer's disease (AD), and idiopathic normal‐pressure hydrocephalus. Among the subjects with dementia, the proportion with parkinsonism was higher in the non‐AD dementia group.Conclusion(s)Parkinsonism occurs in association with several diseases in elderly people. Parkinsonism was also found to be commonly associated with cognitive impairment.