24-Hour Urine Samples Are More Reproducible Than Spot Urine Samples for Evaluation of Iodine Status in School-Age Children
24-Hour Urine Samples Are More Reproducible Than Spot Urine Samples for Evaluation of Iodine Status in School-Age Children
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DOI：
10.3945/jn.115.215806
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发表时间：
2016-01-01
影响因子：
4.2
通讯作者：
Zhang, Wanqi
中科院分区：
文献类型：
--
作者：
Chen, Wen;Wu, Yalan;Zhang, Wanqi
背景资料：目的：本研究旨在评价尿碘浓度（UIC）、尿点和24 h尿肌酐浓度以及24 h尿碘排泄量之间的差异学龄儿童重复样本中的（24小时UlE）。方法：对宁晋县和陵县981名儿童进行了2次尿标本采集（24 h和晨尿）。2013年10月和11月采集了宁晋样本，2014年4月和5月采集了陵县样本。晨点尿碘浓度（MUIC），晨点尿肌酐，24小时UIC，24小时尿肌酐测定所有样本。结果：宁津县24 h UIC和24 h UIE在重复采集之间无差异[24 h UIC分别为192和172 μ g/L（P= 0.08）; 24小时UIE分别为123和120 μ g/L（P= 0.56）1，而2013年11月的MUIC低于2013年10月（分别为170和190 μ g/L; P= 0.034）。在陵县，重复采集之间的24小时UIC没有观察到显著差异（分别为230和218 μ g/L; P= 0.79），而2014年5月采集的样本的24小时UIE和MUIC高于2014年4月[24小时UIE分别为161和155 μ g/L MUIC分别为244和203 μ g/L（P< 0.001）。当从两个县的数据相结合，没有观察到重复24小时UIC之间的差异（214与196 μ g/L相比; P= 0.17）和24小时UIE（143与14311相比，μ g/d; P= 0.06），但MUIC在第一次收集中低于第二次收集（分别为199和207 μ g/L; P= 0.002）。24 h UIC和平均UIE的Kappa值均>0.4，而MUIC和平均UIE.Conclusion的K值相对较低，24 h UIC在评价学龄儿童碘营养状况方面比MUIC更准确，重复性更好。
Background: Variation in different urinary measurements for evaluation of iodine status is of concern to clinicians and researchers.Objective: This study evaluated variations between urine iodine concentration (UIC), spot and 24-h urine sample creatinine concentrations, and 24-h urine iodine excretion (24-h UlE) in repeated samples from school-age children.Methods: Urine samples (24 h and morning spot) were collected on 2 occasions from 981 children in Ningjin and Lingxian counties, China. Samples from Ningjin were collected in October and November 2013, and samples from Lingxian were collected in April and May 2014. Morning spot urine iodine concentration (MUIC), morning spot urine creatinine, 24-h UIC, and 24-h urine creatinine were measured in all samples. The 24-h UIE was calculated by multiplying the 24-h UIC by the 24-h urine volume.Results: In Ningjin County, the 24-h UIC and 24-h UIE did not differ between repeated collections [192 and 172 mu g/L,respectively, for 24-h UIC (P= 0.08); 123 and 120 mu g/L, respectively, for 24-h UIE (P= 0.56)1, whereas the MUIC was lower in November 2013 than in October 2013 (170 and 190 mu g/L, respectively; P= 0.034). In Lingxian County, no significant differences were observed in 24-h UIC between the repeated collections (230 and 218 mu g/L, respectively; P= 0.79), whereas the 24-h UIE and MUIC were higher in the samples collected in May 2014 than in April 2014 [161 and 155 mu g/L, respectively, for 24-h UIE (P= 0.002); 244 and 203 mu g/L, respectively, for MUIC (P< 0.001)(.) When data from both counties were combined, no difference was observed between repeated 24-h UIC (214 compared with 196 mu g/L; P= 0.17) and 24-h UIE (143 compared with 14311,mu g/d; P= 0.06), but MUICs were lower in the first collection than in the second collection (199 and 207 mu g/L, respectively; P= 0.002). The kappa values were >0.4 for 24-h UIC and mean UIE, whereas relatively low K values were observed for MUIC and mean UIE.Conclusion: The 24-h UIC was more accurate and reproducible than the MUIC in evaluating iodine status in a large-scale population study of school-age children.