Effects of feeding schedule changes on the circadian phase of the cardiac autonomic nervous system and serum lipid levels
Effects of feeding schedule changes on the circadian phase of the cardiac autonomic nervous system and serum lipid levels
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DOI：
10.1007/s00421-013-2702-z
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发表时间：
2013-10-01
影响因子：
3
通讯作者：
Kawano, Yukari
中科院分区：
文献类型：
--
作者：
Yoshizaki, Takahiro;Tada, Yuki;Kawano, Yukari
本研究的目的是调查是否安排膳食在一天中的早些时候会影响心脏自主神经系统的昼夜节律时相的心率变异性（HRV）和血脂level.Healthy男性年龄21.4 +/-A0.5岁（n = 14），有规律地不吃早餐的习惯参加了这项平行试验，涉及改变喂养时间表。早餐组（EM组，n = 8）的参与者被要求在8：00，13：00和18：00吃三餐，对照组（n = 6）在13：00，18：00和23：00吃2周。在干预前后的测量日，采集空腹血样和24小时心电图记录。频谱分析用于约10分钟的HRV段。计算低频（LF）功率、高频（HF）功率和HF与总功率的比值（%HF），以评估交感迷走神经平衡。心率变异性的昼夜节律的顶相通过非线性最小二乘回归获得。与对照组相比，EM组的甘油三酯、总胆固醇和低密度脂蛋白胆固醇水平显著降低（分别为p = 0.035、0.008和0.004）。EM组心率变异性指标的最大时相提前，LF功率（-3.2 +/-A1.2h）和%HF（-1.2 +/-A0.5h）干预前后差异有统计学意义（p < 0.05）。
The purpose of this study was to investigate whether scheduling meals earlier in the day affects the circadian phase of the cardiac autonomic nervous system as assessed by heart rate variability (HRV) and serum lipid levels.Healthy men aged 21.4 +/- A 0.5 years (n = 14) with a habit of regularly skipping breakfast participated in this parallel trial involving altered feeding schedules. Participants in the early mealtime group (EM group, n = 8) were asked to eat three meals at 8:00, 13:00, and 18:00, and the control group (n = 6) ate at 13:00, 18:00, and 23:00 for 2 weeks. On the measurement day before and after intervention, fasting blood samples and 24-h electrocardiograph recordings were collected. Spectral analysis was used for approximate 10-min HRV segments. Low frequency (LF) power, high frequency (HF) power, and the ratio of HF to total power (%HF) were calculated to assess sympathovagal balance. Acrophases of the circadian rhythm of HRV variables were obtained by nonlinear least squares regression.Triglyceride and total and LDL cholesterol levels were significantly decreased in the EM group when compared with the control group (p = 0.035, 0.008, and 0.004, respectively). Acrophases for HRV variables were advanced in the EM group and their difference between before and after the intervention in LF power (-3.2 +/- A 1.2 h) and %HF (-1.2 +/- A 0.5 h) reached significant level, respectively (p < 0.05).Timing of meals was a key factor in regulating circadian phases of the cardiac autonomic nervous system and lipid metabolism.