Systemic replacement therapy from genetically modified epidermal keratinocytes.

Systemic replacement therapy from genetically modified epidermal keratinocytes.
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来自转基因表皮角质形成细胞的全身替代疗法。

DOI:
10.1046/j.1525-1381.1999.99226.x
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发表时间:
1999
期刊:
Proceedings of the Association of American Physicians.
影响因子:
--
通讯作者:
Taichman,LB
Taichman,LB
中科院分区:
--
文献类型:
--
作者:
Taichman,LB

文献摘要

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表皮角质形成细胞是基因转移和全身递送的潜在载体。我们回顾了显示表皮分泌的蛋白质确实到达循环的数据,并且我们讨论了影响表皮角质形成细胞可以向循环输送多少蛋白质的因素。
Epidermal keratinocytes are a potential vehicle for gene transfer and systemic delivery. We review data showing that epidermis‐secreted protein does indeed reach the circulation, and we discuss factors that bear upon the issue of how much protein epidermal keratinocytes can deliver to the circulation.