Thermal ablation therapeutics based on CNx multi-walled nanotubes
Thermal ablation therapeutics based on CNx multi-walled nanotubes
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发表时间：
2007-12
影响因子：
8
通讯作者：
S. Torti;Fiona Byrne;Orla Whelan;Nicole H. Levi;B. Ucer;M. Schmid;F. Torti;S. Akman;Ji-wen Liu;P. Ajayan;O. Nalamasu;D. Carroll
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作者：
S. Torti;Fiona Byrne;Orla Whelan;Nicole H. Levi;B. Ucer;M. Schmid;F. Torti;S. Akman;Ji-wen Liu;P. Ajayan;O. Nalamasu;D. Carroll
我们证明了氮掺杂的多壁碳纳米管（CNx-MWNT）在近红外（NIR）照射下导致肾癌细胞的光烧蚀破坏。此外，我们发现有效的热传导和细胞毒性取决于纳米管的长度：正如经典天线理论所预测的那样，有效的近红外耦合发生在纳米管长度超过刺激辐射波长一半的纳米管上。我们还证明，这种辐射通过诱导过程加热纳米管，导致显着的热量传递到周围介质和细胞在非常小的辐射剂量下死亡。这种细胞死亡直接归因于培养中产生的光热效应，因为无论是红外照射本身还是CNx-MWNT对细胞都没有毒性。
We demonstrate that nitrogen doped, multi-walled carbon nanotubes (CNx-MWNT) result in photo-ablative destruction of kidney cancer cells when excited by near infrared (NIR) irradiation. Further, we show that effective heat transduction and cellular cytotoxicity depends on nanotube length: effective NIR coupling occurs at nanotube lengths that exceed half the wavelength of the stimulating radiation, as predicted in classical antenna theory. We also demonstrate that this radiation heats the nanotubes through induction processes, resulting in significant heat transfer to surrounding media and cell killing at extraordinarily small radiation doses. This cell death was attributed directly to photothermal effect generated within the culture, since neither the infrared irradiation itself nor the CNx-MWNT were toxic to the cells.