Separate Hemodynamic Roles for Chloride and Sodium in Deoxycorticosterone Acetate-Salt Hypertension
Separate Hemodynamic Roles for Chloride and Sodium in Deoxycorticosterone Acetate-Salt Hypertension
复制标题
氯和钠在去氧皮质酮醋酸盐高血压中的不同血流动力学作用
DOI：
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发表时间：
1990
期刊：
影响因子：
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通讯作者：
A. Jimenez
中科院分区：
文献类型：
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作者：
J. Passmore;A. Jimenez
Abstract It has been reported that both sodium and chloride ions must be injested to induce the elevated blood pressure of deoxycorticosterone acetate (DOCA)-salt-sensitive hypertension. This study was designed to determine the separate roles of the sodium and chloride ions in the altered hemodynamics underlying the high blood pressure. DOCA pellets (75 mg) were implanted in uninephrectomized rats and the animals were then fed one of four diets: (i) high sodium chloride, (ii) high sodium-low chloride, (iii) high chloride-low sodium, or (iv) low sodium chloride. Blood pressures were measured weekly by tail-cuff plethysmography for 5 weeks and the animals were then subjected to a terminal experiment to measure cardiac output by thermodilution technique, renal blood flow by electromagnetic flow probe, and direct arterial pressure. Blood pressure in the DOCA-high NaCl group was significantly greater (P<0.05) compared with that of the DOCA-low NaCl group (160 ± 3 mm Hg vs 124 ± 2 mm Hg, respectively) at 5 weeks after treatment; all other groups were not significantly different from the DOCA-low NaCl group. Cardiac output was significantly greater in DOCA-treated rats consuming diets high in sodium (44 ± 2 ml/min/100 g) or sodium chloride (40 ± 2 ml/min/100 g) compared with animals consuming low sodium chloride (31 ± 2 ml/min/100 g; P < 0.01 for each comparison). Direct intraarterial blood pressure and renal blood flow were used to calculate renal vascular resistance. Renal vascular resistance was increased in those DOCA-treated rats consuming diets high in chloride (42 ± 3 mm Hg/ml/min/100 g) and high sodium chloride (54 ± 3 mm Hg/ml/min/100 g) compared with rats consuming low sodium chloride (30 ± 3 mm Hg/ml/min/100 g; P < 0.01 for each). It appears that elevations in cardiac output are associated with increased dietary sodium and act in synergy with the elevations in renal vascular resistance associated with increased dietary chloride. Increases in both cardiac output and renal vascular resistance are involved in the maintenance of elevated blood pressure in the DOCA-salt-sensitive model of hypertension.
