Quantitative Monte Carlo-Based 90Y SPECT Reconstruction
Quantitative Monte Carlo-Based 90Y SPECT Reconstruction
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DOI：
10.2967/jnumed.112.119131
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发表时间：
2013-09-01
影响因子：
9.3
通讯作者：
de Jong, Hugo W. A. M.
中科院分区：
文献类型：
--
作者：
Elschot, Mattijs;Lam, Marnix G. E. H.;de Jong, Hugo W. A. M.
评价肿瘤和健康组织的辐射吸收剂量是Y-90微球放射性栓塞治疗肝脏恶性肿瘤越来越感兴趣。这项工作的目的是介绍和验证一种新的重建方法，定量Y-90韧致辐射SPECT，以改善治疗后剂量测定。方法：一个快速蒙特卡罗模拟器适用于Y-90，并纳入统计重建算法（SPECT-MC）。在重建过程中，通过蒙特卡罗模拟对从完整Y-90能谱采样的所有光子的光子散射和衰减进行建模。能量和距离相关的准直器检测器的响应与预先计算的卷积核建模。美国电气制造商协会2007/国际电工委员会2008图像质量体模用于定量评价SPECT-MC的性能，并与最先进的临床SPECT重建和PET进行比较。在5例连续接受放射性栓塞治疗的患者中评价了SPECT、PET和SPECT-MC估计的肝脏放射吸收剂量。结果：与最先进的临床Y-90 SPECT重建相比，SPECT-MC大大提高了图像对比度（e.例如，在一个实施例中，对于37 mm球体，从25%降低到88%），并以较高的图像噪声为代价降低了肺插入物中的平均剩余计数误差（从73%降低到15%）。SPECT-MC的图像噪声和平均计数误差低于PET。图像对比度在较大的球体（直径>= 28 mm）中较高，但在较小的球体中较低（
The evaluation of radiation absorbed doses in tumorous and healthy tissues is of increasing interest for Y-90 microsphere radioembolization of liver malignancies. The objectives of this work were to introduce and validate a new reconstruction method for quantitative Y-90 bremsstrahlung SPECT to improve posttreatment dosimetry. Methods: A fast Monte Carlo simulator was adapted for Y-90 and incorporated into a statistical reconstruction algorithm (SPECT-MC). Photon scatter and attenuation for all photons sampled from the full Y-90 energy spectrum were modeled during reconstruction by Monte Carlo simulations. The energy-and distance-dependent collimator-detector response was modeled with precalculated convolution kernels. The National Electrical Manufacturers Association 2007/International Electrotechnical Commission 2008 image quality phantom was used to quantitatively evaluate the performance of SPECT-MC in comparison with those of state-of-the-art clinical SPECT reconstruction and PET. The liver radiation absorbed doses estimated by SPECT, PET, and SPECT-MC were evaluated in 5 patients consecutively treated with radioembolization. Results: In comparison with state-of-the-art clinical Y-90 SPECT reconstruction, SPECT-MC substantially improved image contrast (e. g., from 25% to 88% for the 37-mm sphere) and decreased the mean residual count error in the lung insert (from 73% to 15%) at the cost of higher image noise. Image noise and the mean count error were lower for SPECT-MC than for PET. Image contrast was higher in the larger spheres (diameter of >= 28 mm) but lower in the smaller spheres (