Indoleamine 2,3-dioxygenase-2; a new enzyme in the kynurenine pathway
Indoleamine 2,3-dioxygenase-2; a new enzyme in the kynurenine pathway
复制标题
DOI：
10.1016/j.biocel.2008.01.005
复制
发表时间：
2009-03-01
影响因子：
4
通讯作者：
Hunt, Nicholas H.
中科院分区：
文献类型：
--
作者：
Ball, Helen J.;Yuasa, Hajime J.;Hunt, Nicholas H.
色氨酸代谢的犬尿氨酸途径将氨基酸色氨酸转化为许多具有生物活性的代谢物。该途径的第一个也是限速步骤是将色氨酸转化为 N-甲酰犬尿氨酸，直到最近，该反应还被认为是由色氨酸 2,3-双加氧酶和吲哚胺 2,3-双加氧酶这两种酶中的任何一种进行的。第三种酶，吲哚胺 2,3-双加氧酶-2、吲哚胺 2,3-双加氧酶样蛋白或原吲哚胺 2,3-双加氧酶（1DO2、IDO-2、INDOLI 或原 IDO）。最近对这项活动进行了描述。编码 IDO2 的基因与吲哚胺 2,3-双加氧酶基因相邻且结构相似，这两个小鼠基因都使用多个启动子来表达具有交替 S' 外显子的转录物。 IDO2蛋白在海洋肾脏、肝脏、男性和女性生殖系统中表达。这两种 IDO 酶可以利用相似范围的底物，但它们对某些抑制剂的选择性不同。 1-甲基-n-色氨酸对1DO2的选择性抑制表明IDO2活性可能在抑制肿瘤免疫反应中发挥作用。 (C) 2009 Elsevier Ltd. 保留所有权利。
The kynurenine pathway of tryptophan metabolism converts the amino acid tryptophan into a number of biologically active metabolites. The first and rate-limiting step in this pathway is the conversion of tryptophan to N-formylkynurenine and until recently this reaction was thought to he performed by either of two enzymes, tryptophan 2,3-dioxygenase and indoleaminc 2,3-dioxygenase. A third enzyme, indoleamine 2,3-dioxygenase-2, indoleamine 2,3-dioxygenase-like protein or proto-indoleamine 2,3-dioxygenase (1DO2, IDO-2, INDOLI or proto-IDO). with this activity recently has been described. The gene encoding IDO2 is adjacent and structurally similar to the indoleamine 2,3-dioxygenase gene and both mouse genes use multiple promoters to express transcripts with alternate S' exons. The IDO2 protein is expressed in the marine kidney, liver, male and female reproductive system. The two IDO enzymes can utilise a similar range of substrates, however they differ in their selectivity for some inhibitors. The selective inhibition of 1DO2 by 1-methyl-n-tryptophan suggests that IDO2 activity may have a role in the inhibition of imnnrne responses to tumours. (C) 2009 Elsevier Ltd. All rights reserved.