Clinical Effects and Safety of 3% Diquafosol Ophthalmic Solution for Patients With Dry Eye After Cataract Surgery: A Randomized Controlled Trial
Clinical Effects and Safety of 3% Diquafosol Ophthalmic Solution for Patients With Dry Eye After Cataract Surgery: A Randomized Controlled Trial
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DOI：
10.1016/j.ajo.2015.12.002
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发表时间：
2016-03-01
影响因子：
4.2
通讯作者：
Lee, Sung Jin
中科院分区：
文献类型：
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作者：
Park, Dae Hyun;Chung, Jin Kwon;Lee, Sung Jin
目得：比较3%地夸磷索和0.1%透明质酸钠治疗白内障术后干眼症的疗效和安全性。设计：随机对照试验。研究人群：在2014年1月至2015年1月期间接受白内障手术的86例干眼症患者的130只眼中，入组并随机分为地夸磷索组和透明质酸钠组。干预措施：地夸磷索组在白内障术后每日使用地夸磷索6次，透明质酸钠组在白内障术后每日使用透明质酸钠6次。主要观察指标：根据眼表疾病指数问卷、泪膜破裂时间（TBUT）、Schirmer I试验、角膜荧光素和结膜丽丝胺绿色染色评分、眼高阶像差（HOA）系列测量、角膜HOA和裸眼远视力试验进行疗效评价。安全性评价基于前房炎症和停用滴眼剂。结果：术后1周客观体征和主观症状加重，术后4周开始明显恢复。地夸磷索组的TBUT显著上级对照组（P
PURPOSE: To compare the efficacies and safety profiles of 3% diquafosol and 0.1% sodium hyaluronate in patients with dry eye after cataract surgery.DESIGN: Randomized controlled trial.METHODS: SETTING: Soonchunhyang University Hospital, Seoul, South Korea. STUDY POPULATION: In all, 130 eyes of 86 dry eye patients who had undergone cataract surgery between January 2014 and January 2015 were enrolled and randomly divided into a diquafosol group and a sodium hyaluronate group. INTERVENTION: The diquafosol group used diquafosol 6 times a day and the hyaluronate group used sodium hyaluronate 6 times a day after cataract surgery. MAIN OUTCOME MEASURES: Evaluations of efficacy were conducted based on an Ocular Surface Disease Index questionnaire, tear breakup time (TBUT), Schirmer I test, corneal fluorescein and conjunctival lissamine green staining scores, serial measurement of ocular higher-order aberrations (HOAs), corneal HOAs, and uncorrected distance visual acuity test. Safety evaluations were based on anterior chamber inflammation and discontinuation of the eye drops.RESULTS: Objective signs and subjective symptoms were aggravated at 1 week postoperatively and began to recover significantly 4 weeks after surgery. The diquafosol group showed significantly superior TBUT (P