Neuroprotective properties of resveratrol in different neurodegenerative disorders
Neuroprotective properties of resveratrol in different neurodegenerative disorders
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DOI：
10.1002/biof.118
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发表时间：
2010-09-01
期刊：
影响因子：
6
通讯作者：
Forloni, Gianluigi
中科院分区：
文献类型：
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作者：
Albani, Diego;Polito, Letizia;Forloni, Gianluigi
天然植物化合物白藜芦醇多年来一直被认为是一种潜在的抗癌药物，但最近它也引起了神经科学家的注意，因为它显示出神经保护作用并激活sirtuins家族成员SIRT 1。Sirtuins是具有优先脱乙酰酶活性的酶。人类sirtuins由7个基因（SIRT 1 -7）编码。研究最多的sirtuin是SIRT 1，其参与几种生理和病理过程，包括细胞凋亡、自噬、糖尿病、癌症、心血管疾病和神经变性。白藜芦醇在体外和体内阿尔茨海默病（AD）模型中都具有神经保护特征，但已证明其在缺血性中风、帕金森病、亨廷顿病和癫痫中也是有益的。在这里，我们总结了体外和体内实验结果，强调白藜芦醇作为神经保护生物因子的可能作用，特别是专注于AD。
The natural phytocompound resveratrol has been considered for many years a potential anticancer drug, but recently it has come to the attention of neuroscientist too, as it displays neuroprotective actions and activates the sirtuins' family member SIRT1. Sirtuins are enzymes with preferential deacetylase activity. Human sirtuins are coded by seven genes (SIRT1-7). The most investigated sirtuin is SIRT1 which is involved in several physiologic and pathologic processes including apoptosis, autophagy, diabetes, cancer, cardiovascular disorders, and neurodegeneration. Resveratrol has neuroprotective features both in vitro and in vivo in models of Alzheimer's disease (AD), but it has proved to be beneficial also in ischemic stroke, Parkinson's disease, Huntington's disease, and epilepsy. Here, we summarize the in vitro and in vivo experimental results highlighting the possible role of resveratrol as neuroprotective biofactor with a particular focus on AD.