Switching from high-fidelity replicases to low-fidelity lesion-bypass polymerases
Switching from high-fidelity replicases to low-fidelity lesion-bypass polymerases
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DOI：
10.1016/j.gde.2004.02.002
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发表时间：
2004-04-01
影响因子：
4
通讯作者：
Woodgate, R
中科院分区：
文献类型：
--
作者：
Plosky, BS;Woodgate, R
除了细胞的正常复制酶外，受损DNA的复制通常需要DNA聚合酶。最近的研究已经开始揭示从高保真复制聚合酶到低保真度translesion聚合酶的转换，这种转换发生在停滞的复制叉上。真核生物的复制钳通过泛素化、SUMO化或磷酸化进行后修饰。据信，这样的修饰有助于调节跨损伤聚合酶接近新生引物末端。
Replication of damaged DNA often requires a DNA polymerase in addition to the cell's normal replicase. Recent research has begun to shed light on the switch from a high-fidelity replicative polymerase to a low-fidelity translesion polymerase that occurs at a stalled replication fork. A picture is emerging in which eukaryotic replicative clamps are posttranslationally modified by ubiquitination, SUMOylation or phosphorylation. It is believed that such modifications help to regulate the access of translesion polymerases to the nascent primer terminus.