Neurotransmitter interactions in schizophrenia - Therarpeutic implications
Neurotransmitter interactions in schizophrenia - Therarpeutic implications
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DOI：
10.1016/s0006-3223(99)00117-1
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发表时间：
1999-11-15
影响因子：
10.6
通讯作者：
Carlsson, ML
中科院分区：
文献类型：
--
作者：
Carlsson, A;Waters, N;Carlsson, ML
在过去的五年里，对新的和改进的抗精神病药物的搜索已经升级。在寻找无毒的氯氮平复制品的时代之后，出现了几种不同的研究路线，其中一些研究追求传统的多巴胺轨迹，尽管研究水平更高，而另一些研究则专注于其他神经递质，如5-羟色胺和谷氨酸。关于复杂神经回路中不同神经递质之间相互作用的新知识为通过干扰许多不同的神经递质来实现抗精神病活性打开了可能性。最耐人寻味的是在动物实验模型中的发现，这表明应该可以通过稳定而不是瘫痪神经回路来缓解精神疾病，从而避免目前使用的药物产生运动和精神副作用的风险。在这些新的类别中，多巴胺能稳定剂和5-HT2A受体拮抗剂似乎是目前最有前途的。从长远来看，通过不同机制干扰谷氨酸功能的药物也可能被证明是有用的，特别是在控制阴性症状方面。生物精神病学1999；46：1388-1395(C)1999生物精神病学学会。
The search for new and improved antipsychotic agents has escalated during the past five years. The era of searching for non-toxic copies of clozapine has been followed by several different lines of research, some of which pursue the traditional dopamine track, although at a higher level of sophistication, whereas others focus on other neurotransmitters, such as serotonin and glutamate. Emerging knowledge about the interactions between different neurotransmitters in complex neurocircuits opens up possibilities for achieving antipsychotic activity by interfering with many different neurotransmitters. Most intriguing is the finding in animal experimental models, indicating that it should be possible to alleviate psychotic conditions by stabilizing rather than paralyzing neurocircuits, thus avoiding the risk of motor and mental side effects of the currently used drugs. Among these new classes dopaminergic stabilizers and 5-HT2A receptor antagonists seem to offer most promise at present. In a longer perspective, drugs interfering with glutamate function via different mechanisms may also turn out to be useful, especially in the control of negative symptoms. Biol Psychiatry 1999; 46:1388-1395 (C) 1999 Society of Biological Psychiatry.