Comparison of visceral fat area measured by CT and bioelectrical impedance analysis in Chinese patients with gastric cancer: a cross-sectional study
Comparison of visceral fat area measured by CT and bioelectrical impedance analysis in Chinese patients with gastric cancer: a cross-sectional study
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中国胃癌患者CT内脏脂肪面积与生物电阻抗分析比较：横断面研究
DOI：
10.1136/bmjopen-2019-036335
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发表时间：
2020-01-01
期刊：
影响因子：
2.9
通讯作者：
Bian, Xiaojie
中科院分区：
文献类型：
--
作者：
Gao, Bo;Liu, Yu;Bian, Xiaojie
目标 生物电阻抗分析 (BIA) 是一种简单且廉价的估计身体成分的方法。然而，BIA 的准确性尚不清楚。我们的目的是评估 BIA 估算胃癌患者内脏脂肪面积 (VFA) 的准确性。研究设计 这是一项横断面研究，比较 BIA 估算 VFA 的准确性与 CT 测量的金标准方法。通过 CT 和 BIA 测量入组患者的 VFA。脐部CT VFA≥100 cm2被认为是内脏肥胖。两种方法之间的可靠性通过组内相关系数（ICC）进行评估，一致性通过Bland-Altman方法进行评估（95％的一致性限度）。受试者工作特征曲线下面积（AUROC）用于评估 BIA 诊断内脏肥胖的性能。背景 这项研究是在中国进行的。研究对象 2017年1月1日至2018年12月1日，共有157名诊断为胃癌的患者入组。结果 总体而言，患者 CT 和 BIA 的 VFA 分别为 84.39±46.43 cm2 和 71.94±22.44 cm2。 BIA 估计的 VFA 与使用 Pearson 检验通过 CT 测量的 VFA 呈正相关（r=0.650，p<0.001）。总体而言，两种方法的 ICC 为 0.675。两次测量之间的平均偏差为 12.45±36.13 cm2。 95% 的一致性限值范围为 -58.36 cm2 至 83.26 cm2。通过 BIA 诊断内脏肥胖的截止值为 81 cm2（AUROC：0.822，p<0.001，95% CI 0.758 至 0.887）。结论 BIA测量的VFA与CT测量的VFA具有良好的可靠性。然而，两种方法的绝对值不可互换。对于中国人群中的胃癌患者，BIA 诊断内脏肥胖的 VFA 临界值为 81 cm2。
Objectives Bioelectrical impedance analysis (BIA) is a simple and inexpensive method to estimate body composition. However, the accuracy of BIA is unknown. We aimed to assess the accuracy of BIA in estimating visceral fat area (VFA) in patients with gastric cancer. Study design This was a cross-sectional study comparing the accuracy of BIA in estimating VFA with the gold standard method measured by CT. VFA was measured in enrolled patients both by CT and BIA. VFA by CT at umbilical level ≥100 cm2 was considered as visceral obesity. Reliability between the two methods was assessed by intraclass correlation coefficient (ICC) and consistency was assessed by Bland-Altman method (95% limits of agreement). The area under the receiver operating characteristic curve (AUROC) was used to assess the performance of BIA in diagnosing visceral obesity. Setting The study was conducted in China. Participants From 1 January 2017 to 1 December 2018, a total of 157 patients diagnosed with gastric cancer were enrolled. Results Overall, VFA by CT and BIA in patients was 84.39±46.43 cm2 and 71.94±22.44 cm2, respectively. VFA estimated by BIA was positively correlated with VFA measured by CT using Pearson’s test (r=0.650, p<0.001). Overall, ICC for the two methods was 0.675. The mean bias between the two measurements was 12.45±36.13 cm2. The 95% limits of agreement ranged from −58.36 cm2 to 83.26 cm2. The cut-off value for diagnosing visceral obesity by BIA was 81 cm2 (AUROC: 0.822, p<0.001, 95% CI 0.758 to 0.887). Conclusions VFA measured by BIA showed satisfactory reliability with that measured by CT. However, the absolute values of the two methods were not interchangeable. The cut-off value for VFA by BIA in diagnosing visceral obesity was 81 cm2 for patients with gastric cancer in the Chinese population.