REDUCED ACETYLCHOLINE SENSITIVITY IN DYSTROPHIC MOUSE MYOTUBES INVITRO
REDUCED ACETYLCHOLINE SENSITIVITY IN DYSTROPHIC MOUSE MYOTUBES INVITRO
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DOI：
10.1002/mus.880070112
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发表时间：
1984-01-01
期刊：
影响因子：
3.4
通讯作者：
MOLINARO, M
中科院分区：
文献类型：
--
作者：
COSSU, G;EUSEBI, F;MOLINARO, M
用常规方法研究了正常和营养不良小鼠肌管的乙酰胆碱（ACh）敏感性。营养不良的多核肌管对乙酰胆碱的反应较对照组低。在营养不良的肌管中对ACh的这种降低的敏感性伴随着对125 I-α-受体的结合降低。银环蛇毒素这些结果对肌肉疾病可能的生物学意义进行了讨论。
Acetylcholine (ACh) sensitivity in cultured myotubes from normal or dystrophic mice was investigated using conventional techniques. Dystrophic multinucleate myotubes were less responsive to the ACh with respect to the control preparation. Such a reduced sensitivity to ACh in dystrophic myotubes was accompanied by a reduced binding to 125I-.alpha.-bungarotoxin. The possible biological significance of these results on the muscle disease is discussed.