Cells of the synovium in rheumatoid arthritis. Dendritic cells.
Cells of the synovium in rheumatoid arthritis. Dendritic cells.
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类风湿关节炎中滑膜细胞。树突状细胞。
DOI：
10.1186/ar2200
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发表时间：
2007
影响因子：
4.9
通讯作者：
Thomas, Ranjeny
中科院分区：
文献类型：
--
作者：
Lutzky, Viviana;Hannawi, Suad;Thomas, Ranjeny
树突状细胞是免疫系统的主要抗原呈递和抗原引发细胞。本文综述了树突状细胞在类风湿性关节炎（RA）和动脉粥样硬化（使RA复杂化）的发生中所起的抗原呈递和促炎作用。促进NF-κB活化和TNF和IL-1分泌的各种信号驱动树突状细胞成熟以引发自身特异性反应，并驱动滑膜炎症的持续。这些信号可能包括遗传因素，感染，吸烟，免疫刺激DNA和氧化低密度脂蛋白，主要涉及自身抗体。我们认为RA和动脉粥样硬化的发病机制是密切相关的，RA的血管疾病是由NF-κB的类似和同时触发驱动的。
Dendritic cells are the major antigen-presenting and antigen-priming cells of the immune system. We review the antigen-presenting and proinflammatory roles played by dendritic cells in the initiation of rheumatoid arthritis (RA) and atherosclerosis, which complicates RA. Various signals that promote the activation of NF-κB and the secretion of TNF and IL-1 drive the maturation of dendritic cells to prime self-specific responses, and drive the perpetuation of synovial inflammation. These signals may include genetic factors, infection, cigarette smoking, immunostimulatory DNA and oxidized low-density lipoprotein, with major involvement of autoantibodies. We propose that the pathogenesis of RA and atherosclerosis is intimately linked, with the vascular disease of RA driven by similar and simultaneous triggers to NF-κB.