The role of 1‐O‐alkyl‐2‐acetyl‐sn‐glyceryl‐3‐phosphorylcholine (AcGEPC) and palmitoyl‐lysophosphatidate in the responses of human blood platelets to collagen and thrombin
The role of 1‐O‐alkyl‐2‐acetyl‐sn‐glyceryl‐3‐phosphorylcholine (AcGEPC) and palmitoyl‐lysophosphatidate in the responses of human blood platelets to collagen and thrombin
复制标题
1-O-烷基-2-乙酰基-sn-甘油基-3-磷酸胆碱（AcGEPC）和棕榈酰-溶血磷脂酸酯在人血小板对胶原蛋白和凝血酶的反应中的作用
DOI：
10.1016/0014-5793(83)81066-7
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发表时间：
1983
期刊：
影响因子：
3.5
通讯作者：
R. Wallis
中科院分区：
文献类型：
--
作者：
T. Hallam;M. Scrutton;R. Wallis
1‐O‐烷基‐2‐乙酰基‐sn‐甘油‐3‐磷酸胆碱（1‐O‐alkylAcGEPC）和溶血磷脂棕榈酰酯的激动剂预孵育，使人血小板脱敏，对胶原的聚集或分泌反应没有影响，但在阿司匹林处理过的血小板中，对凝血酶的反应抑制了30-40%。1‐O‐烷基lacgepc和溶血磷脂棕榈酰并不是相加性的。尽管在这些条件下它们可能在对凝血酶的反应中起一定作用，但结果与1‐O‐alkylAcGEPC或溶血磷酸酯是在阻止前列腺素内酯过氧化氢合成时观察到的对胶原反应的介质的提议不一致。
Desensitisation of human blood platelets to the effects of 1‐O‐alkyl‐2‐acetyl‐sn‐glyceryl‐3‐phosphorylcholine (1‐O‐alkylAcGEPC) and palmityl‐lysophosphatidate by pre‐incubation with these agonists has no effect on the aggregatory or secretory responses to collagen but causes 30–40% inhibition of these responses to thrombin in aspirin‐treated platelets. The effects of 1‐O‐alkylAcGEPC and palmitoyl‐lysophosphatidate are not additive. The results are not consistent with the proposal that 1‐O‐alkylAcGEPC or lysophosphatidate are the mediators for the responses to collagen observed when prostaglandinendo‐peroxide synthesis is prevented, although they may play some role in the responses to thrombin under these conditions.
乙酰甘油醚磷酸胆碱对体外人血小板功能的影响。
影响因子：
20.3
作者：
Marcus,AJ;Safier,LB;Ullman,HL;Wong,KT;Broekman,MJ;Weksler,BB;Kaplan,KL
通讯作者：
Kaplan,KL