Dosimetric comparison of left-sided whole breast irradiation with 3DCRT, forward-planned IMRT, inverse-planned IMRT, helical tomotherapy, and topotherapy
Dosimetric comparison of left-sided whole breast irradiation with 3DCRT, forward-planned IMRT, inverse-planned IMRT, helical tomotherapy, and topotherapy
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DOI：
10.1016/j.radonc.2011.01.004
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发表时间：
2011-08-01
影响因子：
5.7
通讯作者：
Cannon, George M.
中科院分区：
文献类型：
--
作者：
Schubert, Leah K.;Gondi, Vinai;Cannon, George M.
背景和目的：比较左侧全乳腺常规和调强放疗（IMRT）治疗计划techniques.Materials and Methods：治疗计划创建为10个连续的患者。三维适形放疗（3DCRT）、正向计划调强放疗（for-IMRT）和反向计划调强放疗（inv-IMRT）使用两个切线射束。对于IMRT，每个射束最多使用四个段。对于螺旋断层治疗（HT）计划，关键结构的小射束入口和/或出口被阻挡。局部治疗计划使用静态机架角度，同时进行治疗床平移和反向计划强度调制，使用两个切线光束。计划被规范化为50戈伊，95%的撤回PTV.Results：目标最大剂量减少与调强放疗相比，3DCRT，进一步减少HT，局部治疗，和inv-IMRT。FIT导致心脏和同侧肺最大剂量最低，但平均剂量较高。inv-IMRT和局部治疗减少同侧肺平均和最大剂量相比，3DCRT和为IMRT.Conclusions：所有评估的方式提供了足够的覆盖完整的乳房。HT、局部治疗和inv-IMRT可以减少靶组织和正常组织的高剂量，尽管HT导致大体积正常组织的低剂量增加。与3DCRT相比，For-IMRT改善了靶区均匀性，但程度低于反向计划模式。(C)2011爱思唯尔爱尔兰有限公司保留所有权利。放射治疗与肿瘤学100（2011）241-246
Background and purpose: To compare left-sided whole breast conventional and intensity-modulated radiotherapy (IMRT) treatment planning techniques.Materials and methods: Treatment plans were created for 10 consecutive patients. Three-dimensional conformal radiotherapy (3DCRT), forward-planned IMRT (for-IMRT), and inverse-planned IMRT (inv-IMRT) used two tangent beams. For-IMRT utilized up to four segments per beam. For helical tomotherapy (HT) plans, beamlet entrance and/or exit to critical structures was blocked. Topotherapy plans, which used static gantry angles with simultaneous couch translation and inverse-planned intensity modulation, used two tangent beams. Plans were normalized to 50 Gy to 95% of the retracted PTV.Results: Target max doses were reduced with for-IMRT compared to 3DCRT, which were further reduced with HT, topotherapy, and inv-IMRT. FIT resulted in lowest heart and ipsilateral lung max doses, but had higher mean doses. Inv-IMRT and topotherapy reduced ipsilateral lung mean and max doses compared to 3DCRT and for-IMRT.Conclusions: All modalities evaluated provide adequate coverage of the intact breast. HT, topotherapy, and inv-IMRT can reduce high doses to the target and normal tissues, although HT results in increased low doses to large volume of normal tissue. For-IMRT improves target homogeneity compared with 3DCRT, but to a lesser degree than the inverse-planned modalities. (C) 2011 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 100 (2011) 241-246