Case-control study of medical history and idiopathic pulmonary fibrosis in Japan
Case-control study of medical history and idiopathic pulmonary fibrosis in Japan
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DOI：
10.1111/j.1440-1843.2005.00742.x
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发表时间：
2005-09-01
期刊：
影响因子：
6.9
通讯作者：
Tanaka, H
中科院分区：
文献类型：
--
作者：
Miyake, Y;Sasaki, S;Tanaka, H
一些流行病学研究表明，患者过去的病史可能会增加发展为特发性肺纤维化(IPF)的风险。在日本一项以医院为基础的多中心病例对照研究中，评估了特定病史与IPF风险之间的关系。研究纳入了104名40岁或以上的IPF患者，他们在过去两年内根据最新的标准被诊断出来。对照组，年龄在40岁或以上，包括56名确诊为急性细菌性肺炎的住院患者和4名普通感冒的门诊患者。调整了年龄、性别、地区、吸烟年限、就业状况、职业暴露和体重指数。高血压、高脂血症、冠心病、糖尿病、丙型肝炎病毒感染、结核病、哮喘、特应性皮炎和过敏性鼻炎的病史与IPF的风险没有统计学意义上的相关性，尽管患者患过敏性鼻炎的可能性比对照组更高，哮喘的可能性更小。孩子有过敏性鼻炎病史，但没有哮喘或特应性皮炎，与IPF的风险增加显著相关。这些发现表明，过敏性鼻炎的遗传易感性可能与IPF的风险增加有关。
A few epidemiological studies have indicated that a patient's past medical history may contribute to the risk of developing idiopathic pulmonary fibrosis (IPF). A relationship between a history of selected disorders and the risk of IPF was assessed in a multicentre hospital-based case-control study in Japan.Included in the study were 104 patients of IPF, aged 40 years or over, who had been diagnosed within the previous 2 years, in accordance with the most recent criteria. Control subjects, aged 40 years or over, consisted of 56 hospitalized patients diagnosed as having acute bacterial pneumonia and four outpatients with the common cold. Adjustment was made for age, gender, region, pack-years of smoking, employment status, occupational exposure and BMI.Medical histories of hypertension, hyperlipidaemia, coronary heart disease, diabetes mellitus, hepatitis C virus infection, tuberculosis, asthma, atopic dermatitis and allergic rhinitis were not statistically significantly associated with the risk of IPF, although cases were more likely to have suffered from allergic rhinitis and less likely to have been asthmatics than control subjects. Having a child with a history of allergic rhinitis, but not of asthma or atopic dermatitis, was significantly related to an increased risk of IPF.These findings suggest that a genetic predisposition to allergic rhinitis may be associated with an increased risk of IPF.