The Influence of Environmental Factors on Ovarian Function, Follicular Genesis, and Oocyte Quality
The Influence of Environmental Factors on Ovarian Function, Follicular Genesis, and Oocyte Quality
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DOI：
10.1007/978-981-33-4187-6_3
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发表时间：
2021-01-01
期刊：
影响因子：
--
通讯作者：
Zeng, Haitao
中科院分区：
文献类型：
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作者：
Huang, Jiana;Zeng, Haitao
环境中普遍存在内分泌干扰化学物质（EDC）。流行病学数据表明，不孕症患病率的增加可能与众多化学物质有关。接触 EDC 可能会对生殖系统产生重大不利影响，包括生育能力、卵巢储备功能和性类固醇激素水平。本章介绍了 EDC 的常见暴露方式、起源及其对卵巢功能、卵泡发生和卵母细胞质量的影响。此外，我们还将回顾卵巢发育的起源和生理学，并从人类和动物数据中探讨EDCs作用于卵巢的机制。然后，我们将重点关注双酚 A (BPA)，它已被证明会降低生育能力和卵巢储备，并在动物和人类模型中破坏类固醇生成。最后，我们将讨论未来的预防方向和解决方法。
Endocrine-disrupting chemicals (EDCs) exist ubiquitously in the environment. Epidemiological data suggest that the increasing prevalence of infertility may be related to the numerous chemicals. Exposure to EDCs may have significant adverse impacts on the reproductive system including fertility, ovarian reserve, and sex steroid hormone levels. This chapter covers the common exposure ways, the origins of EDCs, and their effects on ovarian function, follicular genesis, and oocyte quality. Furthermore, we will review the origin and the physiology of ovarian development, as well as explore the mechanisms in which EDCs act on the ovary from human and animal data. And then, we will focus on the bisphenol A (BPA), which has been shown to reduce fertility and ovarian reserve, as well as disrupt steroidogenesis in animal and human models. Finally, we will discuss the future direction of prevention and solution methods.