Drag detection and identification by whispering gallery mode optical resonance based sensor
Drag detection and identification by whispering gallery mode optical resonance based sensor
复制标题
基于回音壁模式光学谐振传感器的拖动检测和识别
DOI：
10.1117/12.2028487
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发表时间：
2013
影响因子：
0.7
通讯作者：
A. Ostendorf
中科院分区：
文献类型：
--
作者：
V. Saetchnikov;E. Tcherniavskaia;A. Saetchnikov;G. Schweiger;A. Ostendorf
本文给出了介质微球在抗生素溶液中的回音壁模的共振光谱实验数据。实验证明，在小于1微瓦的激光功率下可以检测到光共振。几种不同代次的抗生素：阿莫西林、阿奇霉素、头孢唑啉、氯霉素、左氧氟沙星、林可霉素、苄青霉素、利福平，在去离子水和生理溶液中都被用于测量。光谱位移和共振光谱的结构是本研究中特别感兴趣的。阻力识别已被开发的多层感知器网络。网络拓扑结构的设计包括：多层感知器的隐藏层的数量，每层中的神经元的数量，神经网络的训练方法，层的激活函数，接收值与所需值的偏差的类型和大小。对于网络训练，采用了各种修正的反向传播误差方法。输入向量对应于6类正在研究的生物物质。分类的结果被认为是积极的，当每个区域，代表一个空间中的某种物质：相对光谱位移的光学共振最大值-相对效率的激发WGM，是单独连接。它被证明，在该文件中描述的方法可以是一个有前途的平台，用于开发敏感的，实验室芯片类型的传感器，可用作不同的药物和仪器的蛋白质组学，基因组学，药物发现和膜研究的快速诊断工具。
Experimental data on optical resonance spectra of whispering gallery modes of dielectric microspheres in antibiotic solutions under varied in wide range concentration are represented. Optical resonance was demonstrated could be detected at a laser power of less than 1 microwatt. Several antibiotics of different generations: Amoxicillin, Azithromycin, Cephazolin, Chloramphenicol, Levofloxacin, Lincomicin Benzylpenicillin, Riphampicon both in deionized water and physiological solution had been used for measurements. Both spectral shift and the structure of resonance spectra were of specific interest in this investigation. Drag identification has been performed by developed multilayer perceptron network. The network topology was designed included: a number of the hidden layers of multilayered perceptron, a number of neurons in each of layers, a method of training of a neural network, activation functions of layers, type and size of a deviation of the received values from required values. For a network training the method of the back propagation error in various modifications has been used. Input vectors correspond to 6 classes of biological substances under investigation. The result of classification was considered as positive when each of the region, representing a certain substance in a space: relative spectral shift of an optical resonance maxima - relative efficiency of excitation of WGM, was singly connected. It was demonstrated that the approach described in the paper can be a promising platform for the development of sensitive, lab-on-chip type sensors that can be used as an express diagnostic tools for different drugs and instrumentation for proteomics, genomics, drug discovery, and membrane studies.