Weight loss reduces interleukin-18 levels in obese women
Weight loss reduces interleukin-18 levels in obese women
复制标题
DOI：
10.1210/jc.87.8.3864
复制
发表时间：
2002-08-01
影响因子：
5.8
通讯作者：
Giugliano, D
中科院分区：
文献类型：
--
作者：
Esposito, K;Pontillo, A;Giugliano, D
肥胖与发生动脉粥样硬化的风险增加有关，这可能至少部分是由脂肪组织促炎细胞因子分泌增加介导的。我们检验了这样的假设：肥胖女性的 IL-18 循环水平升高，并且会因体重减轻而降低。在 40 名肥胖（体重指数为 36.4 +/- 3.1 kg/m(2)）女性样本中，我们发现血浆 IL-18 水平高于 40 名正常体重对照女性（P < 0.01），并且与体重（r = 0.46；P < 0.01）和内脏脂肪（腰臀比；r = 0.39；P < 0.01）呈正相关。热量限制引起的体重减轻（大于或等于原始体重的 10%）超过 1 年，IL-18 水平从 247 (204/309) 降低至 147 (111/210) pg/ml（中位数和 25%/75%；P < 0.01），与体重指数和腰臀比的变化呈正相关。在肥胖女性中，IL-18 水平与体重和腹部脂肪沉积有关；减肥是降低 IL-18 水平的重要干预措施。 IL-18可能是一种在人类肥胖中发挥作用的新型细胞因子。
Obesity is associated with an increased risk of developing atherosclerosis, which may be mediated, at least in part, by increased secretion of proinflammatory cytokines by adipose tissue. We examined the hypothesis that circulating levels of IL-18 were elevated in obese women and would be reduced by weight loss. In a sample of 40 obese (body mass index, 36.4 +/- 3.1 kg/m(2)) women we found that plasma IL-18 levels were higher than in 40 normal weight control women (P < 0.01) and were positively associated with body weight (r = 0.46; P < 0.01) and visceral fat (waist to hip ratio; r = 0.39; P < 0.01). Caloric restriction-induced weight loss (greater than or equal to10% of original weight) over 1 yr reduced IL-18 levels from 247 (204/309) to 147 (111/210) pg/ml (medians and 25%/75%; P < 0.01), positively associated with changes in body mass index and waist to hip ratio. In obese women, IL-18 levels are associated with body weight and abdominal fat deposition; weight loss is an important intervention to reduce IL-18 levels. IL-18 may be a novel cytokine operating in human obesity.