GONADAL-HORMONES ORGANIZE AND MODULATE THE CIRCADIAN SYSTEM OF THE RAT
GONADAL-HORMONES ORGANIZE AND MODULATE THE CIRCADIAN SYSTEM OF THE RAT
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DOI：
10.1152/ajpregu.1981.241.1.r62
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发表时间：
1981-01-01
影响因子：
--
通讯作者：
ALBERS, HE
中科院分区：
文献类型：
--
作者：
ALBERS, HE
本文观察了去性腺的成年雄性、雌性和围产期雄激素雌性大鼠在恒定黑暗条件下植入含胆固醇(C)或雌二醇-17β的硅胶胶囊前后的昼夜轮动节律。(E)。活动节律的自由运行周期(？)在包膜植入前，围产期雄激素暴露的动物有缩短的趋势。给予C并不能可靠地改变tau。在任何组织中。E显著缩短了tau。在出生第3天注射芝麻油的女性中100%。在第3天注射3.5微克丙酸睾丸酮的女性和男性，E缩短或延长，这种变化的方向和幅度以tau为单位。围产期雄激素的存在不会消除大鼠昼夜节律系统对雌激素的敏感性，因为雌激素改变tau的方式取决于其预处理的长度。
The circadian wheel-running rhythms of gonadectomized adult male, female and perinatally androgenized female rats, maintained in constant darkness, were examined before and after implantation of Silastic capsules containing cholesterol (C) or estradiol-17.beta. (E). The free-running period of the activity rhythm (.tau.) before capsule implantation tended to the shorter in animals exposed to perinatal androgen. Administration of C did not reliably alter .tau. in any group. E significantly shortened .tau. in 100% of females injected with sesame oil on day 3 of life. In females, injected with 3.5 .mu.g testosterone propionate on day 3, and males, E shortened or lengthened .tau., with the direction and magnitude of this change in .tau. inversely related to the length of the individual''s pretreatment .tau.. The presence of perinatal androgen does not eliminate the sensitivity of the circadian system of the rat to estrogen, since estrogen alters .tau. in a manner that depends on its pretreatment length.