Hemoglobin expression in nonerythroid cells: novel or ubiquitous?
Hemoglobin expression in nonerythroid cells: novel or ubiquitous?
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DOI：
10.1155/2014/803237
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发表时间：
2014
影响因子：
2
通讯作者：
Reddy KV
中科院分区：
文献类型：
--
作者：
Saha D;Patgaonkar M;Shroff A;Ayyar K;Bashir T;Reddy KV
血红蛋白（Hb）是参与氧（O2）运输的主要蛋白质。红细胞（rbc）含有最多的Hb，由于其独特的结构和可塑性，它们以最佳浓度将O2输送到身体的各个组织。最近有报道称，除了红细胞外，不同来源的上皮细胞等非红系细胞也表达Hb。表达Hb的细胞来自于维持氧稳态至关重要的组织。在肺、神经元、视网膜和子宫内膜等人体组织的上皮细胞中观察到Hb表达。我们的小组最近证明了Hb是由宫颈阴道上皮细胞表达的。我们进一步表明，除了维持O2稳态外，Hb及其衍生的肽通过表现出抗菌活性在保护阴道上皮中发挥不可或缺的作用。在这篇综述中，我们讨论了Hb在阴道上皮细胞中的表达的重要性，它在识别病原体从而降低炎症和/或感染的风险和/或严重程度中的作用，以及Hb表现出抗菌和抗氧化功能的可能机制。
Hemoglobin (Hb) is a major protein involved in transport of oxygen (O2). Red blood cells (RBCs) contain maximum amount of Hb and because of their unique structure and plasticity they transport O2 to various tissues of the body at an optimal concentration. Recently, it has been reported that, apart from RBCs, Hb is also expressed by nonerythroid cells such as epithelial cells of different origin. The cells expressing Hb are from the tissues where maintenance of O2 homeostasis is of paramount importance. Hb expression has been observed in the epithelial cells from human tissues including lungs, neurons, retina, and endometrium. Our group has recently demonstrated that Hb is expressed by the cervicovaginal epithelial cells. We further showed that, apart from maintaining O2 homeostasis, Hb and the peptides derived from it play an indispensable role in the protection of vaginal epithelium by exhibiting antimicrobial activity. In this review, we discuss the significance of Hb expression in vaginal epithelial cells and its role in the recognition of pathogens thereby reducing the risk and/or severity of inflammation and/or infections and the possible mechanism by which Hb exhibits antimicrobial and antioxidative functions.