Ionic liquids in oligosaccharide synthesis: towards nnucin-type glycan probes
Ionic liquids in oligosaccharide synthesis: towards nnucin-type glycan probes
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DOI：
10.1042/bst0381368
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发表时间：
2010-10-01
影响因子：
3.9
通讯作者：
Corfield, Anthony P.
中科院分区：
文献类型：
--
作者：
Galan, M. Carmen;Corfield, Anthony P.
本文概述了粘蛋白及其在生物过程中的作用，同时旨在使读者熟悉目前可用于合成结构定义的粘蛋白类型的葡聚糖探针的工具，包括使用离子液体合成这类重要的寡糖的优点和潜在应用。此外，我们还重点介绍了糖阵列技术的最新发展，该技术可以实现对这类重要的蛋白质-碳水化合物相互作用的高灵敏度和高通量分析。
The present article provides an overview on mucins and their role in biological processes, while aiming to familiarize readers with the current tools available for the synthesis of structurally defined mucin-type glycan probes including the advantages and potential applications of using ionic liquids in the synthesis of this important class of oligosaccharides. Furthermore, we also highlight recent developments in glycoarray technology that can enable high-sensitivity and high-throughput analysis of this important class of protein-carbohydrate interactions.