Pegylated carbon nitride nanosheets for enhanced reactive oxygen species generation and photodynamic therapy under hypoxic conditions
Pegylated carbon nitride nanosheets for enhanced reactive oxygen species generation and photodynamic therapy under hypoxic conditions
复制标题
聚乙二醇化氮化碳纳米片可增强缺氧条件下活性氧的产生和光动力治疗
DOI：
10.1016/j.nano.2020.102167
复制
发表时间：
2020-04-01
影响因子：
5.4
通讯作者：
Cai, Xiaoxiao
中科院分区：
文献类型：
--
作者：
Huang, Qian;Chen, Yang;Cai, Xiaoxiao
光动力学疗法（PDT）在恶性肿瘤治疗中的应用越来越重要;然而，存在几个主要的限制使得其不可能实现最佳治疗效果。我们的目标是开发一种新的皮肤癌光敏药物。本实验制备了四臂聚乙二醇修饰的富氨基石墨相氮化碳纳米片（AGCN-PEG），其在生理溶液中具有良好的稳定性，并在肿瘤细胞中表现出选择性蓄积。在缺氧条件下，AGCN-PEG诱导的PDT能有效抑制A431人表皮样癌细胞的生长。AGCN-PEG与TMPyP 4联合应用后，疗效显著提高。(c)2020爱思唯尔公司All rights reserved.
The application of photodynamic therapy (PDT) is of ever-increasing importance in the treatment of malignant tumors; however, there are several major constraints that make it impossible to achieve optimal therapeutic effects. Our objective is to develop a novel photosensitizing drug for skin cancer. In the experiment, we fabricated four-arm-poly ethylene glycol modified amino-rich graphite phase carbon nitride nanosheets (AGCN-PEG), which have good stability in physiological solution and show selective accumulation in tumor cells. Under hypoxic conditions, the AGCN-PEG induced PDT can effectively inhibit growth on A431 human epidermoid carcinoma cells in vivo and in vitro. What's more, after being combined with TMPyP4, the therapeutic effect of AGCN-PEG was greatly improved. (c) 2020 Elsevier Inc. All rights reserved.