Pd-Catalyzed Denitrative Intramolecular C-H Arylation
Pd-Catalyzed Denitrative Intramolecular C-H Arylation
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DOI：
10.1021/acs.orglett.9b01593
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发表时间：
2019-06-21
期刊：
影响因子：
5.2
通讯作者：
Yamaguchi, Junichiro
中科院分区：
文献类型：
--
作者：
Asahara, Kitty K.;Okita, Toshimasa;Yamaguchi, Junichiro
本文报道了钯催化的硝基芳烃分子内C-H芳基化反应。邻位带有芳基的硝基芳烃可以由2-卤代硝基芳烃通过亲核芳族取代（SNAr）一步制备。在Pd/BrettPhos催化下，芳烃上的C-NO2键以及C-H键的活化以中等至优异的产率生成相应的联芳基键。
A Pd-catalyzed intramolecular C-H arylation of nitroarenes has been developed. Nitroarenes bearing tethered aryl groups at the ortho-position can be readily prepared in one step from 2-halonitroarenes by a nucleophilic aromatic substitution (SNAr). Under Pd/BrettPhos catalysis, activations of the C-NO2 bond as well as the C-H bond on arenes generated the corresponding biaryl linkage in moderate to excellent yields.