Cobalt-Catalyzed Isomerization of 1-Alkenes to (E)-2-Alkenes with Dimethylphenylsilylmethylmagnesium Chloride and Its Application to the Stereoselective Synthesis of (E)-Alkenylsilanes
Cobalt-Catalyzed Isomerization of 1-Alkenes to (E)-2-Alkenes with Dimethylphenylsilylmethylmagnesium Chloride and Its Application to the Stereoselective Synthesis of (E)-Alkenylsilanes
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DOI：
10.1002/asia.200900111
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发表时间：
2009-01-01
影响因子：
4.1
通讯作者：
Oshima, Koichiro
中科院分区：
文献类型：
--
作者：
Kobayashi, Tsuneyuki;Yorimitsu, Hideki;Oshima, Koichiro
在钴-NHC络合物存在下，在二氧六环中，在50 ℃或更高温度下，用二甲基苯基甲硅烷基甲基氯化镁处理1-烯烃，选择性地提供相应的（E）-2-烯烃。该异构化反应适用于分别由相应的高烯丙基硅烷和烯丙基硅烷立体选择性合成（E）-巴豆基硅烷和（E）-1-丙烯基硅烷。
Treatment of 1-alkenes with dimethylphenylsilylmethylmagnesium chloride in the presence of a cobalt-NHC complex in dioxane at 50 degrees C or higher provides the corresponding (E)-2-alkenes selectively. The isomerization is applicable to the stereoselective synthesis of (E)-crotylsilanes and (E)-1-propenylsilanes from the corresponding homoallylsilanes and allylsilanes, respectively.