Synthesis and presence of atrial natriuretic factor in rat ventricle.
Synthesis and presence of atrial natriuretic factor in rat ventricle.
复制标题
大鼠心室中心房钠尿因子的合成和存在。
DOI：
10.1016/0006-291x(87)90300-7
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发表时间：
1987
影响因子：
3.1
通讯作者：
Inagami,T
中科院分区：
文献类型：
--
作者：
Takayanagi,R;Imada,T;Inagami,T
大鼠心室含有免疫反应性心钠素（irANF）和ANF的mRNA。心钠素mRNA在心室和心房的大小一致。高效凝胶过滤色谱显示，84%的心室irANF在对应于ANF的低分子量形式（99-126）的位置处洗脱，16%的irANF在对应于ANF的前体形式的位置处洗脱。自发性高血压大鼠心室irANF含量是Wistar京都大鼠的3倍。这些结果表明，心室合成心钠素响应高血压和过程中的方式不同于心房。
Rat heart ventricles contained immunoreactive atrial natriuretic factor (irANF) and mRNA for ANF. The size of ANF mRNA in the ventricle was identical with that of the atria. High performance gel filtration chromatography showed that 84% of ventricular irANF elutes at a position corresponding to the low molecular weight form of ANF(99–126)and 16% of irANF elutes at a position corresponding to the precursor form of ANF. The irANF content of the ventricles of spontaneously hypertensive rats was 3 times as much as that of Wistar Kyoto rats. These results suggest that ventricle synthesizes ANF in response to hypertension and processes in a manner different from that in atria.