Lumbar dura mater biomechanics: Experimental characterization and scanning electron microscopy observations
Lumbar dura mater biomechanics: Experimental characterization and scanning electron microscopy observations
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DOI：
10.1097/00000539-199906000-00022
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发表时间：
1999-06-01
影响因子：
5.7
通讯作者：
Contro, R
中科院分区：
文献类型：
--
作者：
Runza, M;Pietrabissa, R;Contro, R
关于人体硬脑膜的解剖结构，目前尚无共识。特别是，胶原纤维的取向，这是生物力学行为的责任，仍然存在争议。本工作的目的是评价腰椎硬脑膜的力学性能和显微结构。我们进行了纵向和周向的实验力学表征，并对组织进行了扫描电子显微镜观察。身体解剖时从6名受试者的腰背部(T12-L4/L5)取人硬脑膜标本，屠宰时取2只牛的腰背部硬脑膜标本。人和牛组织的纵向抗拉强度和硬度均强于周向。硬脑膜的扫描电子显微镜观察表明，胶原纤维主要沿纵向取向，这是其在该方向上具有较强抗拉强度的原因。我们得出结论，硬脑膜在所研究的两个方向上有不同的力学响应，因为纤维取向主要是纵向的。在这项实验工作中，我们研究了人腰椎硬脑膜的结构和功能关系。我们对硬脑膜标本进行了力学测试和显微镜观察。结果表明，硬脑膜主要由纵向取向的胶原纤维组成，这是该方向组织阻力较大的原因。
There is no consensus about the anatomical structure of human dura mater. In particular, the orientation of collagen fibers, which are responsible for biomechanical behavior, is still controversial. The aim of this work was to evaluate the mechanical properties and the microstructure of the lumbar dura mater. We performed experimental mechanical characterization in longitudinal and circumferential directions and a scanning electron microscopy observation of the tissue. Specimens of human dura mater were removed from the dorsal-lumbar region (T12-L4/L5) of six subjects at autopsy; specimens of bovine dorsal-lumbar dura mater were obtained from two animals at slaughter. Human and bovine tissues both exhibited stronger tensile strength and stiffness in the longitudinal than in the circumferential direction. Scanning electron microscopy observations of dura mater showed that the collagen fibers are mainly oriented in a longitudinal direction, which accounts for its stronger tensile strength in this direction. We conclude that dura mater has a different mechanical response in the two directions investigated because the fiber orientation is predominantly longitudinal. Implications: In this experimental work, we studied the structural and functional relationship of human lumbar dura mater. We performed mechanical tests and microscopic observations on dura mater samples. The results show that the dura mater is mainly composed of longitudinally oriented collagen fibers, which account for higher tissue resistance in this direction.